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Tdark
CLDN22
Claudin-22

Protein Summary
Description
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is intronless and overlaps the 3' UTR of the WWC2 gene (GeneID: 80014) on the opposite strand. [provided by RefSeq, Aug 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323319
  • ENSP00000318113
  • ENSG00000177300

Symbol
  • CLDN21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.58
tissue
0.52
cell type or tissue
0.49
pathway
0.46
metabolite
0.45


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.21   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 65   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.21   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
claudin 22
701348
Species
Name
OMA
EggNOG
Inparanoid
Macaque
claudin 22
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8N7P3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
Cell junction organization (R-HSA-446728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-cell junction organization
Reactome
Tight junction interactions
Name
Explore in Pharos
Explore in Source
Cell junction organization
Cell-Cell communication
Cell-cell junction organization
Tight junction interactions
Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (27)
1 – 10 of 27
CLDN12
Tbio
Novelty: 0.04404633
Score: 0.943
Data Source: STRINGDB
CLDN23
Tbio
Novelty: 0.12349944
Score: 0.916
Data Source: STRINGDB
CLDN17
Tbio
Novelty: 0.23348754
Score: 0.912
Data Source: STRINGDB
CLDN11
Tbio
Novelty: 0.00275436
Score: 0.911
Data Source: STRINGDB
CLDN9
Tbio
Novelty: 0.06435094
Score: 0.911
Data Source: STRINGDB
CLDN19
Tbio
Novelty: 0.02391772
Score: 0.91
Data Source: STRINGDB
CLDN3
Tbio
Novelty: 0.00286252
Score: 0.909
Data Source: STRINGDB
CLDN20
Tdark
Novelty: 0.50330636
Score: 0.908
Data Source: STRINGDB
CLDN10
Tbio
Novelty: 0.02175843
Score: 0.907
Data Source: STRINGDB
CLDN8
Tbio
Novelty: 0.02218455
Score: 0.907
Data Source: STRINGDB
Publication Statistics
PubMed Score  0.21

PubMed score by year
PubTator Score  7.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer