Tbio AMER2 APC membrane recruitment protein 2

Protein Summary

Description

Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex.

Uniprot Accession IDs

• Q8N7J2
• Q5RL80
• Q5VX56
• Q8N593
• Q96NN5
• Amer2

Gene Name

• AMER2

Ensembl ID

• ENST00000357816
• ENSP00000350469
• ENSG00000165566
• ENST00000515384
• ENSP00000426528

Symbol

• FAM123A
• FAM123A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.66
cell type or tissue	0.65
PubMedID	0.59
histone modification site profile	0.48
cell line	0.46

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.66   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 29   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.66   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 29   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0