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Tbio
AMER2
APC membrane recruitment protein 2

Protein Summary
Description
Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357816
  • ENSP00000350469
  • ENSG00000165566
  • ENST00000515384
  • ENSP00000426528

Symbol
  • FAM123A
  • FAM123A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.66
cell type or tissue
0.65
PubMedID
0.59
histone modification site profile
0.48
cell line
0.46


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.21   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 29   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.21   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 29   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
1
1
1
27.3
triglyceride measurement
1
1
1
4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
1
27.3
triglyceride measurement
1
4
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
APC membrane recruitment protein 2
VGNC:13066
452495
Macaque
APC membrane recruitment protein 2
708730
Mouse
MGI:1919375
72125
Pig
APC membrane recruitment protein 2
100624576
Chicken
APC membrane recruitment protein 2
CGNC:66326
418939
Species
Name
OMA
EggNOG
Inparanoid
Chimp
APC membrane recruitment protein 2
Macaque
APC membrane recruitment protein 2
Mouse
Pig
APC membrane recruitment protein 2
Chicken
APC membrane recruitment protein 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8N7J2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (31)
1 – 10 of 31
ARHGEF4
Tbio
Novelty:  0.01722153
Score:  0.776
Data Source:  STRINGDB
MTMR6
Tbio
Family:  Enzyme
Novelty:  0.13067072
Score:  0.715
Data Source:  STRINGDB
ARHGEF9
Tbio
Novelty:  0.01577146
Score:  0.712
Data Source:  STRINGDB
COL23A1
Tbio
Novelty:  0.17988368
Score:  0.583
Data Source:  STRINGDB
CLASP2
Tbio
Novelty:  0.0353308
Score:  0.576
Data Source:  STRINGDB
DTX1
Tbio
Family:  Enzyme
Novelty:  0.00972217
Score:  0.532
Data Source:  STRINGDB
OR52I2
Tdark
Family:  oGPCR
Novelty:  7.56687898
Score:  0.528
Data Source:  STRINGDB
GABRG2
Tclin
Family:  IC
Novelty:  0.00819163
Score:  0.516
Data Source:  STRINGDB
OR51G1
Tdark
Family:  oGPCR
Novelty:  11.10204082
Score:  0.499
Data Source:  STRINGDB
ADAM23
Tbio
Family:  Enzyme
Novelty:  0.02974247
Score:  0.486
Data Source:  STRINGDB
Publication Statistics
PubMed Score  4.21

PubMed score by year
PubTator Score  2.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer