Tdark CBLL2 E3 ubiquitin-protein ligase CBLL2

Protein Summary

Description

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:20657603). May operate on tyrosine-phosphorylated SRC substrates (PubMed:22252131). This gene encodes a member of the zinc finger domain-containing protein family. This family member contains both a RING-type and a C2H2-type of zinc finger domain, and it may function as an E3 ubiquitin-protein ligase. Protein localization suggests a role in human sperm production and quality control. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• Q8N7E2
• A0AV29
• A0AV31
• E3SBK4
• Q6DJY9

Gene Name

• CBLL2

Ensembl ID

• ENST00000323684
• ENSP00000323348
• ENSG00000175809

Symbol

• ZNF645
• CT138
• HAKAIL
• ZNF645

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

PANTHER Classes

Protein / Ligase / E3 Ubiquitin-protein Ligase Cbll2

DTO Classes

Protein / Enzyme / Ligase / E3 Ubiquitin-protein Ligase Znf645

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.5   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 77   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.5   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0