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Tdark
CBLL2
E3 ubiquitin-protein ligase CBLL2

Protein Classes
Protein Summary
Description
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:20657603). May operate on tyrosine-phosphorylated SRC substrates (PubMed:22252131). This gene encodes a member of the zinc finger domain-containing protein family. This family member contains both a RING-type and a C2H2-type of zinc finger domain, and it may function as an E3 ubiquitin-protein ligase. Protein localization suggests a role in human sperm production and quality control. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323684
  • ENSP00000323348
  • ENSG00000175809

Symbol
  • ZNF645
  • CT138
  • HAKAIL
  • ZNF645
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.54   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 77   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.54   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Cbl proto-oncogene like 2
VGNC:1180
473530
Macaque
zinc finger protein 645
698427
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Cbl proto-oncogene like 2
Macaque
zinc finger protein 645
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8N7E2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Gene Ontology Terms (5)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (269)
1 – 10 of 269
VIRMA
Tbio
Novelty:  0.05400878
p_int:  1
Score:  0.918
Data Source:  BioPlex,STRINGDB
ZC3H13
Tbio
Novelty:  0.0990341
p_int:  0.999998768
p_ni:  6.5e-8
p_wrong:  0.000001167
Score:  0.534
Data Source:  BioPlex,STRINGDB
SERTAD4
Tdark
Novelty:  0.70786986
p_int:  0.999722634
p_ni:  3.86e-7
p_wrong:  0.00027698
Score:  0.703
Data Source:  BioPlex,STRINGDB
WTAP
Tbio
Novelty:  0.01491546
p_int:  0.998919128
p_ni:  0.001080872
Score:  0.918
Data Source:  BioPlex,STRINGDB
PPP2R2D
Tbio
Family:  Enzyme
Novelty:  0.0658328
p_int:  0.99134781
p_ni:  0.00865219
Score:  0.543
Data Source:  BioPlex,STRINGDB
SRSF10
Tbio
Novelty:  0.01273022
p_int:  0.904643408
p_ni:  0.095356592
Score:  0.204
Data Source:  BioPlex,STRINGDB
UBE2D4
Tbio
Novelty:  0.40836104
Score:  0.941
Data Source:  STRINGDB
CBLB
Tbio
Family:  Enzyme
Novelty:  0.08068177
Score:  0.939
Data Source:  STRINGDB
LNX1
Tbio
Family:  Enzyme
Novelty:  0.01555905
Score:  0.938
Data Source:  STRINGDB
UBE2K
Tbio
Novelty:  0.00214955
Score:  0.926
Data Source:  STRINGDB
Publication Statistics
PubMed Score  3.54

PubMed score by year
PubTator Score  168.16

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer