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Tdark
TRIML2
Probable E3 ubiquitin-protein ligase TRIML2

Protein Summary
Description
This gene encodes a member of the tri-partite motif (TRIM) family of proteins. This protein may be regulated by the tumor suppressor p53 and may regulate p53 through the enhancement of p53 SUMOylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000512729
  • ENSP00000422581
  • ENSG00000179046

Symbol
  • SPRYD6
  • SPRYD6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
gene perturbation
0.47
virus perturbation
0.45
cell line
0.42
protein complex
0.41


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.71   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 48   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.71   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 48   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.2
66.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
66.6
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tripartite motif family like 2
VGNC:1997
471382
Macaque
tripartite motif family like 2
707731
Mouse
MGI:3642989
622117
Rat
RGD:1565382
290766
Dog
tripartite motif family like 2
482902
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tripartite motif family like 2
Macaque
tripartite motif family like 2
Mouse
Rat
Dog
tripartite motif family like 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8N7C3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (1)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Protein modification; protein ubiquitination.
Name
Explore in Pharos
Explore in Source
Protein modification; protein ubiquitination.
Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (33)
1 – 10 of 33
MTM1
Tbio
Family:  Enzyme
Novelty:  0.00413329
p_int:  1
Score:  0.227
Data Source:  BioPlex,STRINGDB
CCDC92
Tbio
Novelty:  0.32125749
p_int:  0.99999983
p_ni:  1.42e-7
p_wrong:  2.8e-8
Data Source:  BioPlex
BORCS5
Tdark
Novelty:  0.59333419
p_int:  0.999998569
p_ni:  0.00000143
Score:  0.189
Data Source:  BioPlex,STRINGDB
ZBTB33
Tbio
Family:  TF
Novelty:  0.01327474
p_int:  0.999996624
p_ni:  0.000003376
Score:  0.422
Data Source:  BioPlex,STRINGDB
SPEN
Tbio
Novelty:  0.01211011
p_int:  0.999980975
p_ni:  0.000019025
Score:  0.188
Data Source:  BioPlex,STRINGDB
SRGAP2
Tbio
Family:  Enzyme
Novelty:  0.02951755
p_int:  0.999421001
p_ni:  0.000189644
p_wrong:  0.000389355
Score:  0.319
Data Source:  BioPlex,STRINGDB
KXD1
Tdark
Novelty:  0.32146379
p_int:  0.998169057
p_ni:  0.001830943
Score:  0.625
Data Source:  BioPlex,STRINGDB
BLOC1S2
Tbio
Novelty:  0.02346362
p_int:  0.996473258
p_ni:  0.003016942
p_wrong:  0.000509801
Score:  0.416
Data Source:  BioPlex,STRINGDB
PML
Tbio
Novelty:  0.00285474
p_int:  0.982996873
p_ni:  0.017003127
Score:  0.365
Data Source:  BioPlex,STRINGDB
STIP1
Tbio
Novelty:  0.00590952
p_int:  0.946977313
p_ni:  0.053022687
Score:  0.183
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  3.71

PubMed score by year
PubTator Score  2.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer