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Tdark
CSNK1A1L
Casein kinase I isoform alpha-like

Protein Summary
Description
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379800
  • ENSP00000369126
  • ENSG00000180138

Symbol
  • CK1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
interacting protein
0.74
cell type or tissue
0.63
protein domain
0.58
pathway
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.96   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 164   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.96   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (21)
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Gastric cancer
KEGG
Breast cancer
KEGG
Hepatocellular carcinoma
KEGG
Wnt signaling pathway
KEGG
Human papillomavirus infection
Name
Explore in Pharos
Explore in Source
Gastric cancer
Breast cancer
Hepatocellular carcinoma
Wnt signaling pathway
Human papillomavirus infection
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (38)
1 – 10 of 38
FAM170A
Tdark
Novelty: 0.05778712
p_int: 0.999999999
p_wrong: 1e-9
Score: 0.388
Data Source: BioPlex,STRINGDB
AXIN2
Tchem
Novelty: 0.00273189
Score: 0.91
Data Source: STRINGDB
AXIN1
Tbio
Novelty: 0.00175842
Score: 0.906
Data Source: STRINGDB
CTNNB1
Tchem
Novelty: 0.0000744
Score: 0.878
Data Source: STRINGDB
SMO
Tclin
Family: GPCR
Novelty: 0.03235855
Score: 0.866
Data Source: STRINGDB
CSNK1A1
Tchem
Family: Kinase
Novelty: 0.00636472
Score: 0.801
Data Source: STRINGDB
GSK3B
Tclin
Family: Kinase
Novelty: 0.00095115
Score: 0.778
Data Source: STRINGDB
APC
Tbio
Novelty: 0.00168376
Score: 0.723
Data Source: STRINGDB
APC2
Tbio
Novelty: 0.02034048
Score: 0.723
Data Source: STRINGDB
PRKACG
Tbio
Family: Kinase
Novelty: 0.11080061
Score: 0.695
Data Source: STRINGDB
Publication Statistics
PubMed Score  0.96

PubMed score by year
PubTator Score  143.92

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer