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Tbio
KIR3DL3
Killer cell immunoglobulin-like receptor 3DL3

Protein Classes
Protein Summary
Description
Receptor on natural killer cells. May inhibit the activity of NK cells thus preventing cell lysis. Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosin ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
0.98
cell type or tissue
0.85
disease
0.58
cell line
0.49
tissue
0.47


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.95   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.95   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
1
2
48.5
monocyte percentage of leukocytes
1
2
2
44
1
1
0
1.3
26.6
1
1
0
1.1
10.7
1
1
0
1.1
2.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
48.5
monocyte percentage of leukocytes
2
44
0
1.3
26.6
0
1.1
10.7
0
1.1
2.6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8N743-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (2)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (107)
1 – 10 of 107
HLA-C
Tbio
Novelty:  0.00698601
Score:  0.878
Data Source:  STRINGDB
HLA-C
Tbio
Novelty:  0.00698601
Score:  0.878
Data Source:  STRINGDB
HLA-C
Tbio
Novelty:  0.00698601
Score:  0.878
Data Source:  STRINGDB
HLA-C
Tbio
Novelty:  0.00698601
Score:  0.878
Data Source:  STRINGDB
HLA-C
Tbio
Novelty:  0.00698601
Score:  0.878
Data Source:  STRINGDB
HLA-C
Tbio
Novelty:  0.00698601
Score:  0.878
Data Source:  STRINGDB
HLA-C
Tbio
Novelty:  0.00698601
Score:  0.878
Data Source:  STRINGDB
HLA-C
Tbio
Novelty:  0.00698601
Score:  0.878
Data Source:  STRINGDB
HLA-C
Tbio
Novelty:  0.00698601
Score:  0.878
Data Source:  STRINGDB
HLA-C
Tbio
Novelty:  0.00698601
Score:  0.878
Data Source:  STRINGDB
Publication Statistics
PubMed Score  61.95

PubMed score by year
PubTator Score  18.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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