Q8N726
Tumor suppressor ARF
Protein Summary
Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Interacts with COMMD1 and promotes its 'Lys63'-linked polyubiquitination. Interacts wit ...more
- ENST00000530628
- ENSP00000432664
- ENSG00000147889
- ENST00000579755
- ENSP00000462950
- CDKN2
- MLM
- ARF
- MLM
- P14
- P16
- P19
- CMM2
- INK4
- MTS1
- TP16
- CDK4I
- CDKN2
- INK4A
- MTS-1
- P14ARF
- P19ARF
- P16INK4
- P16INK4A
- P16-INK4A
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0 | ||
biological term | 0 | ||
cell line | 0 | ||
cell type or tissue | 0 | ||
cellular component | 0 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 11825.2 (req: < 5)
Gene RIFs: 1908 (req: <= 3)
Antibodies: 1199 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 11825.2 (req: >= 5)
Gene RIFs: 1908 (req: > 3)
Antibodies: 1199 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 44
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (595)
Nearest Tclin Targets (2)
Downstream (2)
Pathways (214)
Reactome (40)
KEGG (18)
PathwayCommons (8)
WikiPathways (148)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle Checkpoints | ||||
Reactome | Cell Cycle, Mitotic | ||||
Reactome | Cellular Senescence | ||||
Reactome | Cellular responses to external stimuli | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cell Cycle | ||||
Cell Cycle Checkpoints | ||||
Cell Cycle, Mitotic | ||||
Cellular Senescence | ||||
Cellular responses to external stimuli | ||||
Viral Interactions (0)
Gene Ontology Terms (49)
Functions (8)
Components (5)
Processes (36)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Direct Assay (IDA) | CAFA | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (58)
Items per page:
1 – 5 of 58
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
7 | 7 | 4 | 1.2 | 98.6 | |||||
cup-to-disc ratio measurement | 4 | 5 | 14 | 98.6 | |||||
10 | 9 | 0 | 1.3 | 98.1 | |||||
8 | 4 | 0 | 1.3 | 96.6 | |||||
5 | 3 | 0 | 1.2 | 94.3 | |||||
Items per page:
1 – 5 of 58
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
4 | 1.2 | 98.6 | |||||
cup-to-disc ratio measurement | 14 | 98.6 | |||||
0 | 1.3 | 98.1 | |||||
0 | 1.3 | 96.6 | |||||
0 | 1.2 | 94.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (2)
1 – 2 of 2
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | cyclin dependent kinase inhibitor 2A | 465021 | ||||||
Opossum | cyclin-dependent kinase inhibitor 2A | 554242 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | cyclin dependent kinase inhibitor 2A | |||||
Opossum | cyclin-dependent kinase inhibitor 2A | |||||
Publication Statistics
PubMed Score 11825.20
PubMed score by year
PubTator Score 6966.99
PubTator score by year
Related Publications
Text Mined References (2150)
GeneRif Annotations (1908)
Items per page:
0 of 0
PMID | Year | Title |
|---|