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Tbio
Q8N726
Tumor suppressor ARF

Protein Summary
Description
Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Interacts with COMMD1 and promotes its 'Lys63'-linked polyubiquitination. Interacts wit ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000530628
  • ENSP00000432664
  • ENSG00000147889
  • ENST00000579755
  • ENSP00000462950

Symbol
  • CDKN2
  • MLM
  • ARF
  • MLM
  • P14
  • P16
  • P19
  • CMM2
  • INK4
  • MTS1
  • TP16
  • CDK4I
  • CDKN2
  • INK4A
  • MTS-1
  • P14ARF
  • P19ARF
  • P16INK4
  • P16INK4A
  • P16-INK4A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11825.2   (req: < 5)
Gene RIFs: 1908   (req: <= 3)
Antibodies: 1199   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11825.2   (req: >= 5)
Gene RIFs: 1908   (req: > 3)
Antibodies: 1199   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 44
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (595)
CDK4
Tclin
Family:  Kinase
Novelty:  0.00036742
Score:  0.999
Data Source:  STRINGDB
CDK6
Tclin
Family:  Kinase
Novelty:  0.00109319
Score:  0.997
Data Source:  STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.997
Data Source:  Reactome,STRINGDB
MDM2
Tchem
Family:  Enzyme
Novelty:  0.00028385
Score:  0.993
Data Source:  Reactome,STRINGDB
MYC
Tchem
Family:  TF
Novelty:  0.00005734
Score:  0.993
Data Source:  STRINGDB
CCND1
Tchem
Novelty:  0.0001186
Score:  0.992
Data Source:  STRINGDB
E2F1
Tbio
Family:  TF
Novelty:  0.00277137
Score:  0.987
Data Source:  STRINGDB
RB1
Tchem
Novelty:  0.00063798
Score:  0.985
Data Source:  STRINGDB
HRAS
Tchem
Family:  Enzyme
Novelty:  0.00008069
Score:  0.984
Data Source:  STRINGDB
ORC5
Tbio
Novelty:  0.02264865
Score:  0.981
Data Source:  STRINGDB
Nearest Tclin Targets (2)
Explore Nearest Tclin Targets
1 – 2 of 2
CDK4
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  16
more:  12 more common pathways
CDK6
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  14
more:  10 more common pathways
Pathways (214)
Cell Cycle (R-HSA-1640170)

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Find Similar Targets
Items per page:
1 – 5 of 40
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Cellular Senescence
Cellular responses to external stimuli
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (49)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
CAFA
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (58)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
7
7
4
1.2
98.6
cup-to-disc ratio measurement
4
5
14
98.6
10
9
0
1.3
98.1
8
4
0
1.3
96.6
5
3
0
1.2
94.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1.2
98.6
cup-to-disc ratio measurement
14
98.6
0
1.3
98.1
0
1.3
96.6
0
1.2
94.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cyclin dependent kinase inhibitor 2A
465021
Opossum
cyclin-dependent kinase inhibitor 2A
554242
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cyclin dependent kinase inhibitor 2A
Opossum
cyclin-dependent kinase inhibitor 2A
Publication Statistics
PubMed Score 11825.20
PubMed score by year
PubTator Score 6966.99
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title