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Tbio
CELF5
CUGBP Elav-like family member 5

Protein Summary
Description
RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. This gene encodes a member of the the CELF/BRUNOL protein family, which contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing and translation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292672
  • ENSP00000292672
  • ENSG00000161082
  • ENST00000541430
  • ENSP00000443498

Symbol
  • BRUNOL5
  • CELF-5
  • BRUNOL5
  • BRUNOL-5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.7
cell type or tissue
0.66
microRNA
0.58
transcription factor
0.49
cell line
0.43


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.36   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 142   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.36   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (34)
CELF3
Tbio
Novelty:  0.01495441
p_int:  0.999919723
p_ni:  1.1e-8
p_wrong:  0.000080266
Score:  0.481
Data Source:  BioPlex,STRINGDB
PUM2
Tbio
Novelty:  0.01849765
p_int:  0.999802818
p_ni:  0.00019718
p_wrong:  2e-9
Score:  0.606
Data Source:  BioPlex,STRINGDB
SMAP2
Tbio
Novelty:  0.70006863
p_int:  0.999781953
p_ni:  0.000218041
p_wrong:  6e-9
Score:  0.195
Data Source:  BioPlex,STRINGDB
PAIP2B
Tbio
Novelty:  0.65592664
p_int:  0.992236735
p_ni:  0.003348363
p_wrong:  0.004414901
Score:  0.586
Data Source:  BioPlex,STRINGDB
TNKS
Tchem
Family:  Enzyme
Novelty:  0.00404545
p_int:  0.987854216
p_ni:  0.012145784
Data Source:  BioPlex
ATXN2
Tbio
Novelty:  0.00373116
p_int:  0.984157148
p_ni:  0.015842852
Score:  0.249
Data Source:  BioPlex,STRINGDB
ERI3
Tbio
Family:  Enzyme
Novelty:  0.08842487
p_int:  0.977388965
p_ni:  0.000425352
p_wrong:  0.022185683
Score:  0.248
Data Source:  BioPlex,STRINGDB
PUM1
Tbio
Novelty:  0.01536723
p_int:  0.97223836
p_ni:  0.02776164
Score:  0.769
Data Source:  BioPlex,STRINGDB
TNKS2
Tchem
Family:  Enzyme
Novelty:  0.00938509
p_int:  0.967885183
p_ni:  0.032114817
Data Source:  BioPlex
IARS2
Tchem
Family:  Enzyme
Novelty:  0.00854621
p_int:  0.942956467
p_ni:  0.057043533
Score:  0.158
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (29)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
4
4
5
97.9
leukocyte count
2
4
4
97.8
myeloid white cell count
2
2
2
95.4
eosinophil count
3
3
5
94.9
eosinophil percentage of leukocytes
2
2
3
90.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
5
97.9
leukocyte count
4
97.8
myeloid white cell count
2
95.4
eosinophil count
5
94.9
eosinophil percentage of leukocytes
3
90.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CUGBP Elav-like family member 5
VGNC:14740
744978
Macaque
CUGBP Elav-like family member 5
721694
Mouse
MGI:2442333
319586
Rat
RGD:1565016
314647
Dog
CUGBP Elav-like family member 5
VGNC:39096
612072
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CUGBP Elav-like family member 5
Macaque
CUGBP Elav-like family member 5
Mouse
Rat
Dog
CUGBP Elav-like family member 5
Publication Statistics
PubMed Score 6.36
PubMed score by year
PubTator Score 1.11
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title