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Tbio
GPR161
G-protein coupled receptor 161

Protein Summary
Description
Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity). The protein encoded by this gene is an orphan G protein-coupled receptor whose ligand is unknown. This gene is overexpressed in triple-negative breast cancer, and disruption of this gene slows the proliferation of basal breast cancer cells. Therefore, this gene is a potential drug target for triple-negative breast cancer. [provided by RefSeq, Mar 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367835
  • ENSP00000356809
  • ENSG00000143147
  • ENST00000367836
  • ENSP00000356810
  • ENST00000367838
  • ENSP00000356812
  • ENST00000537209
  • ENSP00000441039
  • ENST00000539777
  • ENSP00000437576
  • ENST00000546300
  • ENSP00000444348

Symbol
  • RE2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.94
histone modification site profile
0.76
disease perturbation
0.68
biological process
0.65
transcription factor
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 433.75   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 243   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 433.75   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
IDG Resources
Genetic Construct
GPR161-Tango
image for GPR161-Tango
Details:
  • Vector:  addgene66334
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  FLAG
Data:
  • GPR161-Tango
Order Genetic Construct from:
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
3
3
90.7
sex hormone-binding globulin measurement
3
2
3
63
HbA1c measurement
1
1
1
8.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
90.7
sex hormone-binding globulin measurement
3
63
HbA1c measurement
1
8.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
G protein-coupled receptor 161
698934
Mouse
MGI:2685054
240888
Rat
RGD:1563245
289180
Dog
G protein-coupled receptor 161
VGNC:41412
490358
Horse
G protein-coupled receptor 161
VGNC:18525
100051574
Species
Name
OMA
EggNOG
Inparanoid
Macaque
G protein-coupled receptor 161
Mouse
Rat
Dog
G protein-coupled receptor 161
Horse
G protein-coupled receptor 161
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8N6U8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Hedgehog 'off' state (R-HSA-5610787)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hedgehog 'off' state
Reactome
Hedgehog 'on' state
Reactome
Signal Transduction
Reactome
Signaling by Hedgehog
Name
Explore in Pharos
Explore in Source
Hedgehog 'off' state
Hedgehog 'on' state
Signal Transduction
Signaling by Hedgehog
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (64)
1 – 10 of 64
PRKAR1A
Tbio
Family:  Enzyme
Novelty:  0.00311432
p_int:  0.999999973
p_ni:  2.7e-8
Score:  0.981
Data Source:  BioPlex,STRINGDB
PRKACB
Tchem
Family:  Kinase
Novelty:  0.01962222
p_int:  0.999999242
p_ni:  7.58e-7
Score:  0.963
Data Source:  BioPlex,STRINGDB
PRKAR1B
Tbio
Family:  Enzyme
Novelty:  0.05355517
p_int:  0.999998324
p_ni:  0.000001676
Score:  0.98
Data Source:  BioPlex,STRINGDB
BTRC
Tbio
Novelty:  0.00293475
p_int:  0.999247373
p_ni:  0.000752627
Data Source:  BioPlex
PRKACG
Tchem
Family:  Kinase
Novelty:  0.11080061
p_int:  0.996782661
p_ni:  0.003217132
p_wrong:  2.07e-7
Score:  0.979
Data Source:  BioPlex,STRINGDB
FBXW11
Tbio
Novelty:  0.0715377
p_int:  0.993582503
p_ni:  0.006417497
Data Source:  BioPlex
UBE2Q1
Tbio
Novelty:  0.06489765
p_int:  0.991356663
p_ni:  0.005607777
p_wrong:  0.00303556
Score:  0.169
Data Source:  BioPlex,STRINGDB
PRKACA
Tchem
Family:  Kinase
Novelty:  0.03869658
p_int:  0.977925455
p_ni:  0.022074545
Score:  0.982
Data Source:  BioPlex,STRINGDB
USP12
Tbio
Family:  Enzyme
Novelty:  0.0460009
p_int:  0.934456247
p_ni:  0.064966593
p_wrong:  0.00057716
Data Source:  BioPlex
GOLGA5
Tbio
Novelty:  0.04940885
p_int:  0.917276277
p_ni:  0.082723723
Data Source:  BioPlex
Publication Statistics
PubMed Score  433.75

PubMed score by year
PubTator Score  62.17

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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