Tchem SIRT6 NAD-dependent protein deacetylase sirtuin-6

Protein Summary

Description

NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate. This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transferase and histone deacetylase activities, and plays a role in DNA repair, maintenance of telomeric chromatin, inflammation, lipid and glucose metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]

Uniprot Accession IDs

• Q8N6T7
• B2RCD0
• O75291
• Q6IAF5
• Q6PK99
• Q8NCD2
• Q9BSI5
• Q9BWP3
• Q9NRC7
• Q9UQD1

Gene Name

• SIRT6

Ensembl ID

• ENST00000305232
• ENSP00000305310
• ENSG00000077463
• ENST00000337491
• ENSP00000337332

Symbol

• SIR2L6
• SIR2L6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.98
histone modification site profile	0.78
cellular component	0.73
biological term	0.71
phenotype	0.71

Protein Classes

DTO Classes

Protein / Epigenetic Regulator / Eraser / Histone Deacetylase / Hdac Class Iii / Nad-dependent Protein Deacetylase Sirtuin-6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 895.23   (req: < 5)

Gene RIFs: 289   (req: <= 3)

Antibodies: 615   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 895.23   (req: >= 5)

Gene RIFs: 289   (req: > 3)

Antibodies: 615   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0