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Tbio
ARFGAP1
ADP-ribosylation factor GTPase-activating protein 1

Protein Summary
Description
GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity). The protein encoded by this gene is a GTPase-activating protein, which associates with the Golgi apparatus and which interacts with ADP-ribosylation factor 1. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1-bound GTP and is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000353546
  • ENSP00000314615
  • ENSG00000101199
  • ENST00000370275
  • ENSP00000359298
  • ENST00000370283
  • ENSP00000359306
  • ENST00000519273
  • ENSP00000443716
  • ENST00000519604
  • ENSP00000430500

Symbol
  • ARF1GAP
  • ARF1GAP
  • HRIHFB2281
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.78
metabolite
0.78
histone modification site profile
0.75
cellular component
0.68
biological process
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.94   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 346   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.94   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 346   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (18)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
COPI-mediated anterograde transport
Reactome
Clathrin-mediated endocytosis
Reactome
ER to Golgi Anterograde Transport
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPI-dependent Golgi-to-ER retrograde traffic
COPI-mediated anterograde transport
Clathrin-mediated endocytosis
ER to Golgi Anterograde Transport
Gene Ontology Terms (12)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (239)
1 – 10 of 239
INPPL1
Tchem
Family: Enzyme
Novelty: 0.00821462
p_int: 0.999998991
p_ni: 0.000001009
Score: 0.298
Data Source: BioPlex,STRINGDB
MAU2
Tdark
Novelty: 0.00809576
p_int: 0.999998448
p_ni: 7.4e-7
p_wrong: 8.12e-7
Score: 0.253
Data Source: BioPlex,STRINGDB
AP2A1
Tbio
Novelty: 0.19889503
p_int: 0.999890554
p_ni: 0.000109446
Score: 0.934
Data Source: BioPlex,STRINGDB
DIP2B
Tdark
Novelty: 0.22944551
p_int: 0.999877027
p_ni: 0.000122918
p_wrong: 5.5e-8
Score: 0.183
Data Source: BioPlex,STRINGDB
NIPBL
Tbio
Novelty: 0.00501923
p_int: 0.999842431
p_ni: 0.000028401
p_wrong: 0.000129168
Score: 0.324
Data Source: BioPlex,STRINGDB
AP2M1
Tbio
Novelty: 0.01240983
p_int: 0.9998218
p_ni: 0.0001782
Score: 0.922
Data Source: BioPlex,STRINGDB
AURKA
Tchem
Family: Kinase
Novelty: 0.00069833
p_int: 0.999771836
p_ni: 0.000228164
Score: 0.154
Data Source: BioPlex,STRINGDB
AP1B1
Tbio
Novelty: 0.03313791
p_int: 0.999158248
p_ni: 0.000841752
Score: 0.349
Data Source: BioPlex,STRINGDB
FNTB
Tchem
Family: Enzyme
Novelty: 0.13625417
p_int: 0.999021829
p_ni: 0.000974129
p_wrong: 0.000004041
Data Source: BioPlex
AP2A2
Tbio
Novelty: 0.19247594
p_int: 0.99839535
p_ni: 0.00160465
Score: 0.966
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  22.94

PubMed score by year
PubTator Score  41.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer