You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ARFGAP1
ADP-ribosylation factor GTPase-activating protein 1

Protein Summary
Description
GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity). The protein encoded by this gene is a GTPase-activating protein, which associates with the Golgi apparatus and which interacts with ADP-ribosylation factor 1. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1-bound GTP and is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000353546
  • ENSP00000314615
  • ENSG00000101199
  • ENST00000370275
  • ENSP00000359298
  • ENST00000370283
  • ENSP00000359306
  • ENST00000519273
  • ENSP00000443716
  • ENST00000519604
  • ENSP00000430500

Symbol
  • ARF1GAP
  • ARF1GAP
  • HRIHFB2281
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.78
metabolite
0.78
histone modification site profile
0.75
cellular component
0.68
biological process
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.5   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 346   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.5   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 346   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (239)
INPPL1
Tchem
Family:  Enzyme
Novelty:  0.00634126
p_int:  0.999998991
p_ni:  0.000001009
Score:  0.298
Data Source:  BioPlex,STRINGDB
MAU2
Tdark
Novelty:  0.00594861
p_int:  0.999998448
p_ni:  7.4e-7
p_wrong:  8.12e-7
Score:  0.253
Data Source:  BioPlex,STRINGDB
AP2A1
Tbio
Novelty:  0.08554974
p_int:  0.999890554
p_ni:  0.000109446
Score:  0.934
Data Source:  BioPlex,STRINGDB
DIP2B
Tdark
Novelty:  0.14642544
p_int:  0.999877027
p_ni:  0.000122918
p_wrong:  5.5e-8
Score:  0.183
Data Source:  BioPlex,STRINGDB
NIPBL
Tbio
Novelty:  0.00462654
p_int:  0.999842431
p_ni:  0.000028401
p_wrong:  0.000129168
Score:  0.324
Data Source:  BioPlex,STRINGDB
AP2M1
Tbio
Novelty:  0.00769368
p_int:  0.9998218
p_ni:  0.0001782
Score:  0.922
Data Source:  BioPlex,STRINGDB
AURKA
Tchem
Family:  Kinase
Novelty:  0.0010868
p_int:  0.999771836
p_ni:  0.000228164
Score:  0.154
Data Source:  BioPlex,STRINGDB
AP1B1
Tbio
Novelty:  0.03370208
p_int:  0.999158248
p_ni:  0.000841752
Score:  0.349
Data Source:  BioPlex,STRINGDB
FNTB
Tclin
Family:  Enzyme
Novelty:  0.07434994
p_int:  0.999021829
p_ni:  0.000974129
p_wrong:  0.000004041
Data Source:  BioPlex
AP2A2
Tbio
Novelty:  0.08851191
p_int:  0.99839535
p_ni:  0.00160465
Score:  0.966
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (18)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
COPI-mediated anterograde transport
Reactome
Clathrin-mediated endocytosis
Reactome
ER to Golgi Anterograde Transport
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPI-dependent Golgi-to-ER retrograde traffic
COPI-mediated anterograde transport
Clathrin-mediated endocytosis
ER to Golgi Anterograde Transport
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking cessation
2
3
5
92.4
cigarettes per day measurement
3
2
3
91.8
smoking behaviour measurement
1
1
1
78.3
2
2
2
77.8
smoking status measurement
2
1
2
70
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking cessation
5
92.4
cigarettes per day measurement
3
91.8
smoking behaviour measurement
1
78.3
2
77.8
smoking status measurement
2
70
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ADP ribosylation factor GTPase activating protein 1
VGNC:6040
458456
Macaque
ADP ribosylation factor GTPase activating protein 1
719734
Mouse
MGI:2183559
228998
Rat
RGD:708452
246310
Dog
ADP ribosylation factor GTPase activating protein 1
VGNC:38032
612498
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ADP ribosylation factor GTPase activating protein 1
Macaque
ADP ribosylation factor GTPase activating protein 1
Mouse
Rat
Dog
ADP ribosylation factor GTPase activating protein 1
Publication Statistics
PubMed Score 36.50
PubMed score by year
PubTator Score 41.17
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title