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Tdark
TOP6BL
Type 2 DNA topoisomerase 6 subunit B-like

Protein Summary
Description
Isoform 3: Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360962
  • ENSP00000354227
  • ENSG00000173715

Symbol
  • C11orf80
  • TOP6BL
  • TOPOVIBL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.43   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 14   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.43   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 14   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
5
7
93.6
BMI-adjusted waist circumference
2
2
4
90.3
waist circumference
1
1
1
56.2
chronotype measurement
1
1
1
48.5
IGF-1 measurement
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
7
93.6
BMI-adjusted waist circumference
4
90.3
waist circumference
1
56.2
chronotype measurement
1
48.5
IGF-1 measurement
1
44.2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8N6T0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (27)
1 – 10 of 27
OR4K14
Tdark
Family:  oGPCR
Novelty:  4.77119228
Score:  0.726
Data Source:  STRINGDB
OR4N5
Tdark
Family:  oGPCR
Novelty:  6.93604268
Score:  0.712
Data Source:  STRINGDB
TMEM132C
Tdark
Novelty:  0.44360512
Score:  0.683
Data Source:  STRINGDB
ZNF473
Tbio
Family:  TF
Novelty:  0.07957644
Score:  0.668
Data Source:  STRINGDB
FAM122C
Tdark
Novelty:  4.87170475
Score:  0.642
Data Source:  STRINGDB
KLHL4
Tdark
Novelty:  0.25272903
Score:  0.636
Data Source:  STRINGDB
SPO11
Tbio
Novelty:  0.00273994
Score:  0.622
Data Source:  STRINGDB
CCDC85A
Tdark
Novelty:  0.76752741
Score:  0.6
Data Source:  STRINGDB
RCE1
Tchem
Family:  Enzyme
Novelty:  0.01209847
Score:  0.574
Data Source:  STRINGDB
PABPC5
Tdark
Novelty:  0.36077159
Score:  0.572
Data Source:  STRINGDB
Publication Statistics
PubMed Score  3.43

PubMed score by year
PubTator Score  0.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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