Tbio CD177 CD177 antigen

Protein Summary

Description

In association with beta-2 integrin heterodimer ITGAM/CD11b and ITGB2/CD18, mediates activation of TNF-alpha primed neutrophils including degranulation and superoxide production (PubMed:21193407). In addition, by preventing beta-2 integrin internalization and attenuating chemokine signaling favors adhesion over migration (PubMed:28807980). Heterophilic interaction with PECAM1 on endothelial cells plays a role in neutrophil transendothelial migration in vitro (PubMed:17580308). However, appears to be dispensable for neutrophil recruitment caused by bacterial infection in vivo (PubMed:23461681). Acts as a receptor for the mature form of protease PRTN3 allowing its display at the cell surface of neutrophils (PubMed:17244676, PubMed:18462208). By displaying PRTN3 at the neutrophil cell surface, may play a role in enhancing endothelial cell junctional integrity and thus vascular integrity during neutrophil diapedesis (PubMed:23202369). This gene encodes a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation. The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration. Mutations in this gene are associated with myeloproliferative diseases. Over-expression of this gene has been found in patients with polycythemia rubra vera. Autoantibodies against the protein may result in pulmonary transfusion reactions, and it may be involved in Wegener's granulomatosis. A related pseudogene, which is adjacent to this gene on chromosome 19, has been identified. [provided by RefSeq, Apr 2014]

Uniprot Accession IDs

• Q8N6Q3
• Q711Q2
• Q8NCV9
• Q96QH1
• Q9HDA5

Gene Name

• CD177

Ensembl ID

• ENST00000378012
• ENSP00000367251
• ENSG00000204936

Symbol

• NB1
• PRV1
• NB1
• PRV1
• HNA2A
• PRV-1
• HNA-2a
• NB1 GP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.67
biological term	0.53
cellular component	0.53
tissue	0.52
cell line	0.48

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 517.6   (req: < 5)

Gene RIFs: 39   (req: <= 3)

Antibodies: 0   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 517.6   (req: >= 5)

Gene RIFs: 39   (req: > 3)

Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (144)

Explore Interacting Targets

1 – 10 of 144

• See Interactions on String-DB

PRTN3

Tchem

Family:  Enzyme

Novelty:  0.00022728

Score:  0.974

Data Source:  Reactome,STRINGDB

PLAUR

Tchem

Family:  Enzyme

Novelty:  0.00087642

Score:  0.969

Data Source:  STRINGDB

PECAM1

Tbio

Novelty:  0.00013373

Score:  0.964

Data Source:  Reactome,STRINGDB

SLC44A2

Tbio

Family:  Transporter

Novelty:  0.01550561

Score:  0.937

Data Source:  STRINGDB

ITGAM

Tbio

Novelty:  0.00017521

Score:  0.937

Data Source:  STRINGDB

CEACAM8

Tbio

Novelty:  0.00370138

Score:  0.937

Data Source:  STRINGDB

CEACAM1

Tbio

Novelty:  0.0029954

Score:  0.933

Data Source:  STRINGDB

ITGAL

Tclin

Novelty:  0.00099016

Score:  0.93

Data Source:  STRINGDB

CD59

Tbio

Novelty:  0.0008352

Score:  0.926

Data Source:  STRINGDB

CLEC4D

Tbio

Novelty:  0.04119682

Score:  0.913

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (7)

Reactome (7)

Cell surface interactions at the vascular wall (R-HSA-202733)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cell surface interactions at the vascular wall	211 targets	R-HSA-202733
Reactome	Common Pathway of Fibrin Clot Formation	22 targets	R-HSA-140875
Reactome	Formation of Fibrin Clot (Clotting Cascade)	39 targets	R-HSA-140877
Reactome	Hemostasis	666 targets	R-HSA-109582
Reactome	Immune System	2246 targets	R-HSA-168256

Name	Explore in Pharos	Explore in Source
Cell surface interactions at the vascular wall	211 targets	R-HSA-202733
Common Pathway of Fibrin Clot Formation	22 targets	R-HSA-140875
Formation of Fibrin Clot (Clotting Cascade)	39 targets	R-HSA-140877
Hemostasis	666 targets	R-HSA-109582
Immune System	2246 targets	R-HSA-168256

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (26)

Functions (3)

Components (8)

Processes (15)

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Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
calcium-dependent protein binding	Inferred from Physical Interaction (IPI)	UniProtKB
integrin binding	Inferred from Physical Interaction (IPI)	UniProtKB
protease binding	Inferred from Physical Interaction (IPI)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (1)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
cotinine glucuronidation measurement	EFO_0006508	1	1	1		0.4

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 1 of 1

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
cotinine glucuronidation measurement	EFO_0006508	1		0.4

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UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Cell adhesion
Cell membrane
Cell projection
Complete proteome
Direct protein sequencing
Glycoprotein
GPI-anchor
Immunity
Innate immunity

GWAS Trait Find Similar Targets

No Header	No Header
cotinine glucuronidation measurement

MGI Phenotype Find Similar Targets

No Header	No Header
hematopoietic system phenotype
immune system phenotype

IDG Resources

No IDG generated resources found

Orthologs (2)

1 – 2 of 2

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Dog	CD177 molecule	VGNC:38934	612424
Cow	CD177 molecule	VGNC:27006	616350

Species	Name	OMA	EggNOG	Inparanoid
Dog	CD177 molecule
Cow	CD177 molecule

Publication Statistics

PubMed Score 517.60

PubMed score by year

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PubTator Score 570.88

PubTator score by year

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Related Publications

Text Mined References (79)

GeneRif Annotations (39)

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10

0 of 0

PMID	Year	Title