Tbio IL22RA1 Interleukin-22 receptor subunit alpha-1

Protein Summary

Description

Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation. The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10BR/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8N6P7
• A8K839
• B2R9Y9
• Q9HB22
• IL-22 receptor subunit alpha-1

Gene Name

• IL22RA1

Ensembl ID

• ENST00000270800
• ENSP00000270800
• ENSG00000142677

Symbol

• IL22R
• IL22R
• CRF2-9
• IL22R1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.64
virus perturbation	0.64
tissue	0.52
hub protein	0.44
microRNA	0.43

Protein Classes

PANTHER Classes

Protein / Receptor / Cytokine Receptor / Type Ii Cytokine Receptor / Interleukin-22 Receptor Subunit Alpha-1

Protein / Receptor / Cytokine Receptor / Type I Cytokine Receptor / Interleukin-22 Receptor Subunit Alpha-1

Protein / Defense/immunity Protein / Interleukin-22 Receptor Subunit Alpha-1

DTO Classes

Protein / Receptor / Cytokine Receptor / Type Ii Cytokine Receptor / Interleukin-22 Receptor Subunit Alpha-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.48   (req: < 5)

Gene RIFs: 41   (req: <= 3)

Antibodies: 420   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.48   (req: >= 5)

Gene RIFs: 41   (req: > 3)

Antibodies: 420   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0