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Tbio
AOPEP
Aminopeptidase O

Protein Summary
Description
Aminopeptidases catalyze the hydrolysis of amino acid residues from the N-terminus of peptide or protein substrates. Able to cleave angiotensin III to generate angiotensin IV, a bioactive peptide of the renin-angiotensin pathway. Not able to cleave angiotensin I and angiotensin II. May play a role in the proteolytic processing of bioactive peptides in tissues such as testis and heart. This gene encodes a member of the M1 zinc aminopeptidase family. The encoded protein is a zinc-dependent metallopeptidase that catalyzes the removal of an amino acid from the amino terminus of a protein or peptide. This protein may play a role in the generation of angiotensin IV. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000277198
  • ENSP00000277198
  • ENSG00000148120
  • ENST00000297979
  • ENSP00000297979
  • ENST00000375315
  • ENSP00000364464

Symbol
  • C9orf3
  • ONPEP
  • APO
  • AP-O
  • ONPEP
  • C90RF3
  • C9orf3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.43   (req: < 5)
View Publications
Gene RIFs: 2   (req: <= 3)
View Gene RIFs
Antibodies: 83   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.43   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (3)
Metabolism of Angiotensinogen to Angiotensins (R-HSA-2022377)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of Angiotensinogen to Angiotensins
18 targets
R-HSA-2022377
Reactome
Metabolism of proteins
2050 targets
R-HSA-392499
Reactome
Peptide hormone metabolism
88 targets
R-HSA-2980736
Name
Explore in Pharos
Explore in Source
Metabolism of Angiotensinogen to Angiotensins
18 targets
R-HSA-2022377
Metabolism of proteins
2050 targets
R-HSA-392499
Peptide hormone metabolism
88 targets
R-HSA-2980736
Protein-Protein Interactions (36)
1 – 10 of 36
LRRC40
Tdark
Novelty: 7
p_int: 0.999928093
p_ni: 0.000071907
p_wrong: 1e-9
Score: 0.188
Data Source: BioPlex,STRINGDB
ZDHHC17
Tbio
Family: Enzyme
Novelty: 0.03352984
p_int: 0.989136232
p_ni: 0.010858975
p_wrong: 0.000004793
Score: 0.199
Data Source: BioPlex,STRINGDB
TUBA4A
Tchem
Novelty: 0.02626744
p_int: 0.891428458
p_ni: 0.108571542
Data Source: BioPlex
SUZ12
Tbio
Novelty: 0.00668683
p_int: 0.796513922
p_ni: 0.203171611
p_wrong: 0.000314467
Score: 0.189
Data Source: BioPlex,STRINGDB
TUBB3
Tclin
Novelty: 0.00281462
p_int: 0.767165823
p_ni: 0.232834177
Data Source: BioPlex
AGT
Tbio
Novelty: 0.00056146
Score: 0.903
Data Source: Reactome,STRINGDB
DENND1A
Tbio
Novelty: 0.06261011
Score: 0.674
Data Source: STRINGDB
SYNPO2L
Tdark
Novelty: 0.59240506
Score: 0.657
Data Source: STRINGDB
THADA
Tbio
Novelty: 0.02734274
Score: 0.571
Data Source: STRINGDB
TOX3
Tbio
Family: TF
Novelty: 0.02037559
Score: 0.56
Data Source: STRINGDB
Publication Statistics
PubMed Score  58.43

PubMed score by year
PubTator Score  105.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MDIQLDPARDDLPLMANTSHILVKHYVLDLDVDFESQVIEGTIVLFLEDGNRFKKQNSSIEEACQSESNK
1-70
ACKFGMPEPCHIPVTNARTFSSEMEYNDFAICSKGEKDTSDKDGNHDNQEHASGISSSKYCCDTGNHGSE
70-140
DFLLVLDCCDLSVLKVEEVDVAAVPGLEKFTRSPELTVVSEEFRNQIVRELVTLPANRWREQLDYYARCS
140-210
QAPGCGELLFDTDTWSLQIRKTGAQTATDFPHAIRIWYKTKPEGRSVTWTSDQSGRPCVYTVGSPINNRA
210-280
LFPCQEPPVAMSTWQATVRAAASFVVLMSGENSAKPTQLWEECSSWYYYVTMPMPASTFTIAVGCWTEMK
280-350
METWSSNDLATERPFSPSEANFRHVGVCSHMEYPCRFQNASATTQEIIPHRVFAPVCLTGACQETLLRLI
350-420
PPCLSAAHSVLGAHPFSRLDVLIVPANFPSLGMASPHIMFLSQSILTGGNHLCGTRLCHEIAHAWFGLAI
420-490
GARDWTEEWLSEGFATHLEDVFWATAQQLAPYEAREQQELRACLRWRRLQDEMQCSPEEMQVLRPSKDKT
490-560
GHTSDSGASVIKHGLNPEKIFMQVHYLKGYFLLRFLAKRLGDETYFSFLRKFVHTFHGQLILSQDFLQML
560-630
LENIPEEKRLELSVENIYQDWLESSGIPKPLQRERRAGAECGLARQVRAEVTKWIGVNRRPRKRKRREKE
630-700
EVFEKLLPDQLVLLLEHLLEQKTLSPRTLQSLQRTYHLQDQDAEVRHRWCELIVKHKFTKAYKSVERFLQ
700-770
EDQAMGVYLYGELMVSEDARQQQLARRCFERTKEQMDRSSAQVVAEMLF
770-819
MDIQLDPARDDLPLMANTSHILVKHYVLDLDVDFESQVIEGTIVLFLEDGNRFKKQNSSIEEACQSESNKACKFGMPEPCHIPVTNARTFSSEMEYNDFAICSKGEKDTSDKDGNHDNQEHASGISSSKYCCDTGNHGSEDFLLVLDCCDLSVLKVEEVDVAAVPGLEKFTRSPELTVVSEEFRNQIVRELVTLPANRWREQLDYYARCSQAPGCGELLFDTDTWSLQIRKTGAQTATDFPHAIRIWYKTKPEGRSVTWTSDQSGRPCVYTVGSPINNRALFPCQEPPVAMSTWQATVRAAASFVVLMSGENSAKPTQLWEECSSWYYYVTMPMPASTFTIAVGCWTEMKMETWSSNDLATERPFSPSEANFRHVGVCSHMEYPCRFQNASATTQEIIPHRVFAPVCLTGACQETLLRLIPPCLSAAHSVLGAHPFSRLDVLIVPANFPSLGMASPHIMFLSQSILTGGNHLCGTRLCHEIAHAWFGLAIGARDWTEEWLSEGFATHLEDVFWATAQQLAPYEAREQQELRACLRWRRLQDEMQCSPEEMQVLRPSKDKTGHTSDSGASVIKHGLNPEKIFMQVHYLKGYFLLRFLAKRLGDETYFSFLRKFVHTFHGQLILSQDFLQMLLENIPEEKRLELSVENIYQDWLESSGIPKPLQRERRAGAECGLARQVRAEVTKWIGVNRRPRKRKRREKEEVFEKLLPDQLVLLLEHLLEQKTLSPRTLQSLQRTYHLQDQDAEVRHRWCELIVKHKFTKAYKSVERFLQEDQAMGVYLYGELMVSEDARQQQLARRCFERTKEQMDRSSAQVVAEMLF