Tbio OTUD6B Deubiquitinase OTUD6B

Protein Summary

Description

Isoform 1: Deubiquitinating enzyme that may play a role in the ubiquitin-dependent regulation of protein synthesis, downstream of mTORC1 (PubMed:21267069, PubMed:27864334). May associate with the protein synthesis initiation complex and modify its ubiquitination to repress translation (PubMed:27864334). May also repress DNA synthesis and modify different cellular targets thereby regulating cell growth and proliferation (PubMed:27864334). May also play a role in proteasome assembly and function (PubMed:28343629). Isoform 2: Stimulates protein synthesis. Influences the expression of CCND1/cyclin D1 by promoting its translation and regulates MYC/c-Myc protein stability. This gene encodes a member of the ovarian tumor domain (OTU)-containing subfamily of deubiquitinating enzymes. Deubiquitinating enzymes are primarily involved in removing ubiquitin from proteins targeted for degradation. This protein may function as a negative regulator of the cell cycle in B cells. [provided by RefSeq, Nov 2013]

Uniprot Accession IDs

• Q8N6M0
• A8K6I1
• B4DEY0
• Q9NTA4
• Q9Y387

Gene Name

• OTUD6B

Ensembl ID

• ENST00000404789
• ENSP00000384190
• ENSG00000155100
• ENST00000615618
• ENSP00000481196

Symbol

• DUBA5
• DUBA5
• CGI-77
• DUBA-5
• IDDFSDA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.82
microRNA	0.81
transcription factor binding site profile	0.72
tissue sample	0.66
cell line	0.61

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Deubiquitinase Otud6b

Protein / Hydrolase / Protease / Cysteine Protease / Deubiquitinase Otud6b

DTO Classes

Protein / Enzyme / Protease / Cysteine Protease / Otu Domain-containing Protein 6b

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.64   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 140   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.64   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0