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Tbio
CCDC155
Protein KASH5

Protein Summary
Description
As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Required for telomere attachment to nuclear envelope in the prophase of meiosis and for rapid telomere prophase movements implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly. Required for homologue pairing during meiotic prophase in spermatocytes and probably oocytes. Essential for male and female gametogenesis. Recruits cytoplasmic dynein to telomere attachment sites at the nuclear envelope in spermatocytes. In oocytes is involved in meiotic resumption and spindle formation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000447857
  • ENSP00000404220
  • ENSG00000161609

Symbol
  • KASH5
  • KASH5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.58
cellular component
0.57
transcription factor
0.54
microRNA
0.5
tissue
0.46


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.93   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 54   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.93   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (18)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (43)
1 – 10 of 43
SUN1
Tbio
Novelty: 0.00931817
Score: 0.896
Data Source: STRINGDB
TEAD2
Tbio
Family: TF
Novelty: 0.02487024
Score: 0.88
Data Source: STRINGDB
SYNE4
Tbio
Novelty: 0.0739848
Score: 0.878
Data Source: STRINGDB
TERB1
Tdark
Family: TF
Novelty: 0.20863595
Score: 0.826
Data Source: STRINGDB
SYNE3
Tbio
Novelty: 0.06515065
Score: 0.815
Data Source: STRINGDB
DKKL1
Tbio
Novelty: 0.00544618
Score: 0.807
Data Source: STRINGDB
SYNE1
Tbio
Novelty: 0.00315473
Score: 0.784
Data Source: STRINGDB
SYNE2
Tbio
Novelty: 0.01368736
Score: 0.772
Data Source: STRINGDB
SUN2
Tbio
Novelty: 0.01387591
Score: 0.752
Data Source: STRINGDB
SUN3
Tdark
Novelty: 0.09961616
Score: 0.748
Data Source: STRINGDB
Publication Statistics
PubMed Score  6.93

PubMed score by year
PubTator Score  2.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer