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Tbio
ADAMTSL1
ADAMTS-like protein 1

Protein Summary
Description
This gene encodes a secreted protein and member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) family. This protein lacks the metalloproteinase and disintegrin-like domains, which are typical of the ADAMTS family, but contains other ADAMTS domains, including the thrombospondin type 1 motif. This protein may have important functions in the extracellular matrix. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276935
  • ENSP00000276935
  • ENSG00000178031
  • ENST00000327883
  • ENSP00000327887
  • ENST00000380545
  • ENSP00000369918
  • ENST00000380548
  • ENSP00000369921
  • ENST00000380566
  • ENSP00000369940
  • ENST00000542621
  • ENSP00000440472

Symbol
  • ADAMTSR1
  • C9orf94
  • C9orf94
  • PUNCTIN
  • ADAMTSR1
  • ADAMTSL-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.97
protein domain
0.92
transcription factor perturbation
0.88
cell line
0.71
transcription factor
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.99   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.99   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (63)
B3GLCT
Tbio
Family:  Enzyme
Novelty:  0.02398944
p_int:  0.999632669
p_ni:  0.000367331
Score:  0.981
Data Source:  BioPlex,STRINGDB
FHL2
Tbio
Novelty:  0.00501273
p_int:  0.979971827
p_ni:  0.020028133
p_wrong:  4e-8
Score:  0.253
Data Source:  BioPlex,STRINGDB
RSPRY1
Tdark
Novelty:  0.26883105
p_int:  0.963476278
p_ni:  0.03652372
p_wrong:  3e-9
Data Source:  BioPlex
WDCP
Tdark
Novelty:  0.29184907
p_int:  0.918564767
p_ni:  0.081435233
Data Source:  BioPlex
ACOX1
Tchem
Family:  Enzyme
Novelty:  0.00473427
p_int:  0.895517541
p_ni:  0.104482458
p_wrong:  1e-9
Score:  0.183
Data Source:  BioPlex,STRINGDB
FBN2
Tbio
Novelty:  0.00549053
p_int:  0.884442954
p_ni:  0.115557046
Score:  0.491
Data Source:  BioPlex,STRINGDB
GRN
Tbio
Novelty:  0.00096395
p_int:  0.847003185
p_ni:  0.152996815
Data Source:  BioPlex
POFUT2
Tbio
Family:  Enzyme
Novelty:  0.06236603
Score:  0.985
Data Source:  STRINGDB
THBS2
Tbio
Novelty:  0.00310724
Score:  0.941
Data Source:  STRINGDB
CFP
Tbio
Novelty:  0.00063251
Score:  0.941
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Defective B3GALTL causes Peters-plus syndrome (PpS) (R-HSA-5083635)

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Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective B3GALTL causes Peters-plus syndrome (PpS)
Reactome
Disease
Reactome
Diseases associated with O-glycosylation of proteins
Reactome
Diseases of glycosylation
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Defective B3GALTL causes Peters-plus syndrome (PpS)
Disease
Diseases associated with O-glycosylation of proteins
Diseases of glycosylation
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
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Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
5
7
87.6
refractive error measurement
2
2
1
7.4
86.6
Myopia
2
1
0
4.2
61.4
age at onset
1
1
0
7.4
58.4
lymphocyte percentage of leukocytes
1
1
1
56.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
7
87.6
refractive error measurement
1
7.4
86.6
Myopia
0
4.2
61.4
age at onset
0
7.4
58.4
lymphocyte percentage of leukocytes
1
56.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ADAMTS like 1
VGNC:4600
473179
Mouse
MGI:1924989
77739
Dog
ADAMTS like 1
VGNC:37606
474717
Horse
ADAMTS like 1
VGNC:15075
100063467
Cow
ADAMTS like 1 [Source:HGNC Symbol;Acc:HGNC:14632]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ADAMTS like 1
Mouse
Dog
ADAMTS like 1
Horse
ADAMTS like 1
Cow
ADAMTS like 1 [Source:HGNC Symbol;Acc:HGNC:14632]
Publication Statistics
PubMed Score 12.99
PubMed score by year
PubTator Score 6.98
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title