Tbio GCSAM Germinal center-associated signaling and motility protein

Protein Summary

Description

Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation. This gene encodes a protein which may function in signal transduction pathways and whose expression is elevated in germinal cell lymphomas. It contains a putative PDZ-interacting domain, an immunoreceptor tyrosine-based activation motif (ITAM), and two putative SH2 binding sites. In B cells, its expression is specifically induced by interleukin-4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8N6F7
• C9JD17
• C9JUG6

Gene Name

• GCSAM

Ensembl ID

• ENST00000308910
• ENSP00000309487
• ENSG00000174500
• ENST00000460387
• ENSP00000420603
• ENST00000484193
• ENSP00000419485
• ENST00000643065
• ENSP00000493535
• ENSG00000284925
• ENST00000644247
• ENSP00000494547
• ENST00000646639
• ENSP00000496265

Symbol

• GAL
• GCET2
• HGAL
• GCAT2
• GCET2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.84
tissue sample	0.61
tissue	0.56
microRNA	0.52
cell line	0.5

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.61   (req: < 5)

Gene RIFs: 24   (req: <= 3)

Antibodies: 156   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.61   (req: >= 5)

Gene RIFs: 24   (req: > 3)

Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0