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Tdark
RNF182
E3 ubiquitin-protein ligase RNF182

Protein Summary
Description
E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000488300
  • ENSP00000420465
  • ENSG00000180537
  • ENST00000537388
  • ENSP00000441271
  • ENST00000537663
  • ENSP00000443228
  • ENST00000544682
  • ENSP00000442021
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.66
gene perturbation
0.65
histone modification site profile
0.63
transcription factor perturbation
0.61
microRNA
0.59


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.81   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 128   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.81   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ring finger protein 182
707517
Mouse
MGI:3045355
328234
Rat
RGD:1560399
498726
Horse
ring finger protein 182
VGNC:22457
100065188
Cow
ring finger protein 182
VGNC:34040
518996
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ring finger protein 182
Mouse
Rat
Horse
ring finger protein 182
Cow
ring finger protein 182
Pathways (5)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (276)
1 – 10 of 276
RNF19B
Tbio
Family: Enzyme
Novelty: 0.20054824
Score: 0.951
Data Source: STRINGDB
TRAIP
Tbio
Family: Enzyme
Novelty: 0.04163226
Score: 0.94
Data Source: STRINGDB
TRIM9
Tbio
Family: Enzyme
Novelty: 0.06250762
Score: 0.937
Data Source: STRINGDB
UBE2D1
Tbio
Novelty: 0.00865867
Score: 0.937
Data Source: STRINGDB
UBC
Tbio
Novelty: 0.00204643
Score: 0.933
Data Source: STRINGDB
RNF217
Tdark
Family: Enzyme
Novelty: 0.37676903
Score: 0.931
Data Source: STRINGDB
RNF144B
Tbio
Family: Enzyme
Novelty: 0.02487971
Score: 0.929
Data Source: STRINGDB
UBE2Q2
Tbio
Novelty: 0.12491522
Score: 0.926
Data Source: STRINGDB
RNF19A
Tbio
Family: Enzyme
Novelty: 0.0670154
Score: 0.925
Data Source: STRINGDB
RNF130
Tdark
Family: Enzyme
Novelty: 0.26931521
Score: 0.924
Data Source: STRINGDB
Publication Statistics
PubMed Score  2.81

PubMed score by year
PubTator Score  1.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer