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Tdark
LILRA3
Leukocyte immunoglobulin-like receptor subfamily A member 3

Protein Summary
Description
Acts as soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF-alpha production by monocytes. This gene encodes a member of a family of immunoreceptors that are expressed predominantly in monocytes and B cells, and at lower levels in dendritic cells and natural killer cells. The encoded protein lacks the transmembrane region found in other members of this family. It acts as a soluble receptor for class I major histocompatibility complex (MHC) antigens. Alternatively spliced transcript variants encoding different isoforms have been found. This gene is located in a cluster of related genes on chromosome 19 and is polymorphic in human populations, with many individuals containing a deletion of this genomic region. [provided by RefSeq, Mar 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000612127
  • ENSP00000484119
  • ENSG00000278046
  • ENST00000615652
  • ENSP00000482971
  • ENSG00000273884
  • ENST00000617541
  • ENSP00000477708
  • ENSG00000275841
  • ENST00000619638
  • ENSP00000481818
  • ENST00000620589
  • ENSP00000480386
  • ENSG00000276175

Symbol
  • ILT6
  • LIR4
  • HM31
  • HM43
  • ILT6
  • LIR4
  • CD85E
  • ILT-6
  • LIR-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.58
cell line
0.53
tissue
0.47
phenotype
0.45
tissue sample
0.43


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (4)
1 – 4 of 4
LILRB2
Tbio
Novelty:  0.00545569
p_int:  0.999999999
p_wrong:  1e-9
Data Source:  BioPlex
LILRB1
Tbio
Novelty:  0.00463824
p_int:  0.999999994
p_wrong:  6e-9
Data Source:  BioPlex
LILRA1
Tdark
Novelty:  0.17371827
p_int:  0.999999325
p_ni:  1e-9
p_wrong:  6.75e-7
Data Source:  BioPlex
NARS
Tbio
Family:  Enzyme
Novelty:  0.01124207
p_int:  0.998794478
p_ni:  0.001205521
Data Source:  BioPlex
Pathways (7)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
GWAS Traits (44)
Items per page:
1 – 5 of 44
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
12
10
25
99
high density lipoprotein cholesterol measurement
12
10
25
99
apolipoprotein A 1 measurement
2
5
5
97.6
apolipoprotein A 1 measurement
2
5
5
97.6
creatine kinase measurement
5
5
9
96.9
Items per page:
1 – 5 of 44
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
25
99
high density lipoprotein cholesterol measurement
25
99
apolipoprotein A 1 measurement
5
97.6
apolipoprotein A 1 measurement
5
97.6
creatine kinase measurement
9
96.9
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Publication Statistics
PubTator Score 26.74
PubTator score by year