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Tbio
SLC15A4
Solute carrier family 15 member 4

Protein Summary
Description
Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266771
  • ENSP00000266771
  • ENSG00000139370

Symbol
  • PHT1
  • PTR4
  • PHT1
  • PTR4
  • FP12591
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
transcription factor perturbation
0.88
virus perturbation
0.85
transcription factor binding site profile
0.79
molecular function
0.76


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.17   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 63   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.17   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
4
0
1.2
86.8
basophil count
2
1
2
60.4
basophil percentage of leukocytes
1
1
1
43.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
86.8
basophil count
2
60.4
basophil percentage of leukocytes
1
43.8
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 15 member 4
VGNC:8534
452366
Macaque
solute carrier family 15 member 4
716359
Mouse
MGI:2140796
100561
Rat
RGD:708469
246280
Dog
solute carrier family 15 member 4
VGNC:52967
610055
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 15 member 4
Macaque
solute carrier family 15 member 4
Mouse
Rat
Dog
solute carrier family 15 member 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8N697-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Reactome
Proton/oligopeptide cotransporters
Reactome
SLC-mediated transmembrane transport
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Proton/oligopeptide cotransporters
SLC-mediated transmembrane transport
Gene Ontology Terms (12)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (138)
1 – 10 of 138
CXorf21
Tdark
Novelty: 0.30533562
p_int: 0.999909668
p_ni: 0.000090332
Score: 0.661
Data Source: BioPlex,STRINGDB
SLC22A2
Tchem
Family: Transporter
Novelty: 0.00439263
p_int: 0.99909149
p_ni: 0.000878504
p_wrong: 0.000030006
Data Source: BioPlex
NKAIN1
Tdark
Family: Enzyme
Novelty: 0.52190272
p_int: 0.998834133
p_ni: 0.001120224
p_wrong: 0.000045643
Data Source: BioPlex
UPK1A
Tbio
Novelty: 0.01748122
p_int: 0.99879807
p_ni: 0.001201889
p_wrong: 4.1e-8
Data Source: BioPlex
GPR21
Tdark
Family: GPCR
Novelty: 0.90865557
p_int: 0.997806742
p_ni: 0.002164641
p_wrong: 0.000028617
Data Source: BioPlex
LRRC55
Tbio
Family: IC
Novelty: 0.25121277
p_int: 0.997665797
p_ni: 0.002256538
p_wrong: 0.000077666
Data Source: BioPlex
LGALS3
Tchem
Novelty: 0.00032754
p_int: 0.99614208
p_ni: 0.003850162
p_wrong: 0.000007758
Data Source: BioPlex
PTGIR
Tclin
Family: GPCR
Novelty: 0.0091906
p_int: 0.992249258
p_ni: 0.007726707
p_wrong: 0.000024036
Data Source: BioPlex
TNFRSF10C
Tbio
Novelty: 0.0088942
p_int: 0.984982877
p_ni: 0.012733198
p_wrong: 0.002283925
Data Source: BioPlex
GORASP1
Tbio
Novelty: 0.02332405
p_int: 0.984699119
p_ni: 0.015204515
p_wrong: 0.000096366
Data Source: BioPlex
Publication Statistics
PubMed Score  77.17

PubMed score by year
PubTator Score  26.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer