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Tbio
DEFB119
Beta-defensin 119

Protein Summary
Description
Has antibacterial activity. This gene encodes a member of the beta subfamily of defensins. Beta-defensins are antimicrobial peptides that protect tissues and organs from infection by a variety of microorganisms. This gene is found in a cluster with other beta-defensin genes on the long arm of chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339144
  • ENSP00000345768
  • ENSG00000180483
  • ENST00000376315
  • ENSP00000365492
  • ENST00000376321
  • ENSP00000365499

Symbol
  • DEFB120
  • DEFB19
  • DEFB20
  • DEFB20
  • DEFB-19
  • DEFB-20
  • DEFB120
  • ESC42-RELA
  • ESC42-RELB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.82
gene perturbation
0.74
tissue
0.54
phenotype
0.45
transcription factor
0.44


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.77   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 60   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.77   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 60   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
defensin beta 119
574286
Dog
defensin beta 119
VGNC:49716
100683811
Species
Name
OMA
EggNOG
Inparanoid
Macaque
defensin beta 119
Dog
defensin beta 119
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8N690-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Antimicrobial peptides (R-HSA-6803157)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Beta defensins
Reactome
Defensins
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Beta defensins
Defensins
Immune System
Innate Immune System
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (34)
1 – 10 of 34
DEFB123
Tdark
Novelty: 0.17722275
Score: 0.981
Data Source: STRINGDB
DEFB127
Tbio
Novelty: 0.18126756
Score: 0.979
Data Source: STRINGDB
DEFB121
Tdark
Novelty: 2.72797456
Score: 0.977
Data Source: STRINGDB
DEFB132
Tdark
Novelty: 0.43147041
Score: 0.961
Data Source: STRINGDB
DEFB1
Tbio
Novelty: 0.00144458
Score: 0.955
Data Source: STRINGDB
DEFB135
Tdark
Novelty: 2.04107063
Score: 0.952
Data Source: STRINGDB
DEFB128
Tbio
Novelty: 0.30093411
Score: 0.95
Data Source: STRINGDB
DEFB118
Tbio
Novelty: 0.14992977
Score: 0.945
Data Source: STRINGDB
DEFB125
Tdark
Novelty: 0.69005738
Score: 0.943
Data Source: STRINGDB
DEFB126
Tbio
Novelty: 0.05538355
Score: 0.942
Data Source: STRINGDB
Publication Statistics
PubMed Score  1.77

PubMed score by year
PubTator Score  1.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer