Tdark DEFB123 Beta-defensin 123

Protein Summary

Description

Has antibacterial activity. Defensins are cysteine-rich cationic polypeptides that are important in the host immunologic response to invading microorganisms. This antimicrobial protein is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 20q11.1. Two transcript variants, one protein-coding and the other not, have been found for this gene. [provided by RefSeq, Nov 2014]

Uniprot Accession IDs

• Q8N688
• Q5GRF8
• Q5J5C7

Gene Name

• DEFB123

Ensembl ID

• ENST00000376309
• ENSP00000365486
• ENSG00000180424

Symbol

• DEFB23
• DEFB23
• DEFB-23
• ESC42-RELD

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
chemical	0.41
tissue sample	0.36
tissue	0.35
cell line	0.34
biological term	0.33

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.64   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 0   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.64   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0