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Tdark
DEFB123
Beta-defensin 123

Protein Summary
Description
Has antibacterial activity. Defensins are cysteine-rich cationic polypeptides that are important in the host immunologic response to invading microorganisms. This antimicrobial protein is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 20q11.1. Two transcript variants, one protein-coding and the other not, have been found for this gene. [provided by RefSeq, Nov 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376309
  • ENSP00000365486
  • ENSG00000180424

Symbol
  • DEFB23
  • DEFB23
  • DEFB-23
  • ESC42-RELD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
0.41
tissue sample
0.36
tissue
0.35
cell line
0.34
biological term
0.33


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.63   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.63   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
47.7
1
1
0
1.1
36.9
alkaline phosphatase measurement
1
1
1
32.6
smoking status measurement
1
1
1
12.2
TPE interval measurement
1
1
1
2.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
47.7
0
1.1
36.9
alkaline phosphatase measurement
1
32.6
smoking status measurement
1
12.2
TPE interval measurement
1
2.9
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
defensin beta 123
VGNC:6091
742057
Mouse
MGI:2385956
266620
Rat
RGD:1564902
641640
Horse
defensin beta 123
VGNC:51529
102148505
Cow
defensin beta 123
786992
Species
Name
OMA
EggNOG
Inparanoid
Chimp
defensin beta 123
Mouse
Rat
Horse
defensin beta 123
Cow
defensin beta 123
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8N688-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Antimicrobial peptides (R-HSA-6803157)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Beta defensins
Reactome
Defensins
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Beta defensins
Defensins
Immune System
Innate Immune System
Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (36)
1 – 10 of 36
DEFB119
Tbio
Novelty:  0.36154966
Score:  0.981
Data Source:  STRINGDB
DEFB124
Tbio
Novelty:  1.65330827
Score:  0.959
Data Source:  STRINGDB
DEFB129
Tdark
Novelty:  0.26809608
Score:  0.953
Data Source:  STRINGDB
DEFB114
Tbio
Novelty:  0.22206668
Score:  0.946
Data Source:  STRINGDB
DEFB110
Tdark
Novelty:  0.49548192
Score:  0.939
Data Source:  STRINGDB
DEFB126
Tbio
Novelty:  0.05538355
Score:  0.923
Data Source:  STRINGDB
DEFB1
Tbio
Novelty:  0.00144458
Score:  0.922
Data Source:  STRINGDB
DEFB121
Tdark
Novelty:  2.72797456
Score:  0.921
Data Source:  STRINGDB
DEFB116
Tdark
Novelty:  2.72622256
Score:  0.921
Data Source:  STRINGDB
DEFB128
Tbio
Novelty:  0.30093411
Score:  0.92
Data Source:  STRINGDB
Publication Statistics
PubMed Score  5.63

PubMed score by year
PubTator Score  3.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer