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Tbio
CPSF7
Cleavage and polyadenylation specificity factor subunit 7

Protein Summary
Description
Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:8626397, PubMed:17024186, PubMed:29276085). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:8626397, PubMed:17024186). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF7 activates directly the mRNA 3'-processing machinery (PubMed:29276085). Binds to pA signals in ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340437
  • ENSP00000345412
  • ENSG00000149532
  • ENST00000394888
  • ENSP00000378352
  • ENST00000439958
  • ENSP00000397203
  • ENST00000448745
  • ENSP00000407394

Symbol
  • CFIm59
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
disease perturbation
0.83
microRNA
0.71
interacting protein
0.7
virus perturbation
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.98   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 126   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.98   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 126   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
58.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
58.2
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (11)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
Processing of Capped Intronless Pre-mRNA
Reactome
Processing of Intronless Pre-mRNAs
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
Processing of Capped Intronless Pre-mRNA
Processing of Intronless Pre-mRNAs
Gene Ontology Terms (15)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (239)
1 – 10 of 239
JMJD6
Tbio
Family: Enzyme
Novelty: 0.00305479
p_int: 0.999937325
p_ni: 0.000062675
Score: 0.184
Data Source: BioPlex,STRINGDB
CPSF6
Tbio
Novelty: 0.01263178
p_int: 0.999429315
p_ni: 0.000570685
Score: 0.985
Data Source: BioPlex,STRINGDB
P4HA1
Tchem
Family: Enzyme
Novelty: 0.01624726
p_int: 0.99789718
p_ni: 0.00210282
Data Source: BioPlex
DDX20
Tbio
Family: Enzyme
Novelty: 0.01854078
p_int: 0.939391298
p_ni: 0.060608702
Score: 0.309
Data Source: BioPlex,STRINGDB
BCHE
Tclin
Family: Enzyme
Novelty: 0.00031267
p_int: 0.931446107
p_ni: 0.068553893
Score: 0.158
Data Source: BioPlex,STRINGDB
NUDT21
Tbio
Novelty: 0.02174736
Score: 0.999
Data Source: Reactome,STRINGDB
CDC5L
Tbio
Family: TF
Novelty: 0.00663599
Score: 0.998
Data Source: STRINGDB
CPSF3
Tchem
Novelty: 0.01880576
Score: 0.975
Data Source: STRINGDB
CPSF2
Tbio
Novelty: 0.0510853
Score: 0.972
Data Source: STRINGDB
U2AF2
Tbio
Novelty: 0.00590935
Score: 0.967
Data Source: STRINGDB
Publication Statistics
PubMed Score  4.98

PubMed score by year
PubTator Score  2.12

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer