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Tbio
COMMD1
COMM domain-containing protein 1

Protein Summary
Description
Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins. Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1; in vitro promotes CRL E3 activity and dissociates CAND1 from CUL1 and CUL2 (PubMed:21778237). Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity (PubMed:15799966, PubMed:17183367, PubMed:20048074). Involved in the regulation of membrane expression and ubiquitination of SLC12A2 (PubMed:23515529). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits and by promoting their ubiquitination presumably involving NEDD4L. Promotes the localization of SCNN1D to recycling endosomes (PubMed:14645214, PubMed:20237237, PubMed:21741370). Promotes ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311832
  • ENSP00000308236
  • ENSG00000173163

Symbol
  • C2orf5
  • MURR1
  • MURR1
  • C2orf5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
biological process
0.84
kinase perturbation
0.84
transcription factor perturbation
0.84
molecular function
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.19   (req: < 5)
Gene RIFs: 46   (req: <= 3)
Antibodies: 380   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.19   (req: >= 5)
Gene RIFs: 46   (req: > 3)
Antibodies: 380   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
49.5
hemoglobin measurement
1
1
1
40.7
testosterone measurement
1
1
1
37.6
red blood cell density measurement
1
1
1
31.3
amino acid measurement
1
1
2
28.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
49.5
hemoglobin measurement
1
40.7
testosterone measurement
1
37.6
red blood cell density measurement
1
31.3
amino acid measurement
2
28.1
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
copper metabolism domain containing 1
VGNC:212
459266
Macaque
copper metabolism domain containing 1 [Source:HGNC Symbol;Acc:HGNC:23024]
Mouse
MGI:109474
17846
Rat
RGD:1311771
289831
Dog
copper metabolism domain containing 1
VGNC:39491
403590
Species
Name
OMA
EggNOG
Inparanoid
Chimp
copper metabolism domain containing 1
Macaque
copper metabolism domain containing 1 [Source:HGNC Symbol;Acc:HGNC:23024]
Mouse
Rat
Dog
copper metabolism domain containing 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8N668-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Neddylation
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Neddylation
Post-translational protein modification
Gene Ontology Terms (27)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (260)
1 – 10 of 260
COMMD10
Tbio
Novelty:  0.29057641
p_int:  1
Score:  0.997
Data Source:  BioPlex,STRINGDB
COMMD6
Tbio
Novelty:  0.11854363
p_int:  1
Score:  0.993
Data Source:  BioPlex,STRINGDB
COMMD4
Tbio
Novelty:  0.20453574
p_int:  1
Score:  0.992
Data Source:  BioPlex,STRINGDB
COMMD3
Tbio
Novelty:  0.07399068
p_int:  1
Score:  0.991
Data Source:  BioPlex,STRINGDB
COMMD8
Tdark
Novelty:  0.33240242
p_int:  1
Score:  0.983
Data Source:  BioPlex,STRINGDB
FAM45A
Tdark
Novelty:  0.94034891
p_int:  1
Score:  0.847
Data Source:  BioPlex,STRINGDB
CCDC22
Tbio
Novelty:  0.01400901
p_int:  0.999999999
p_ni:  1e-9
Score:  0.99
Data Source:  BioPlex,Reactome,STRINGDB
COMMD5
Tbio
Novelty:  0.16163787
p_int:  0.999999899
p_ni:  1.01e-7
Score:  0.997
Data Source:  BioPlex,STRINGDB
C16orf62
Tdark
Novelty:  0.33867321
p_int:  0.99999949
p_ni:  5.1e-7
Score:  0.946
Data Source:  BioPlex,STRINGDB
CCDC93
Tdark
Novelty:  0.19116791
p_int:  0.999998886
p_ni:  0.000001114
Score:  0.967
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  84.19

PubMed score by year
PubTator Score  49.95

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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