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Tbio
TMEM86B
Lysoplasmalogenase

Protein Summary
Description
Enzyme catalyzing the degradation of lysoplasmalogen. Lysoplasmalogens are formed by the hydrolysis of the abundant membrane glycerophospholipids plasmalogens. May control the respective levels of plasmalogens and lysoplasmalogens in cells and modulate cell membrane properties.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327042
  • ENSP00000321038
  • ENSG00000180089
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.85
tissue sample
0.57
cell line
0.47
cellular component
0.47
metabolite
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.23   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 13   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.23   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 13   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
47.5
phosphatidylethanolamine ether measurement
1
1
1
30.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
47.5
phosphatidylethanolamine ether measurement
1
30.1
Pathways (6)
Acyl chain remodelling of PC (R-HSA-1482788)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acyl chain remodelling of PC
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Phospholipid metabolism
Name
Explore in Pharos
Explore in Source
Acyl chain remodelling of PC
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Phospholipid metabolism
Protein-Protein Interactions (40)
1 – 10 of 40
ENPP6
Tbio
Family: Enzyme
Novelty: 0.06933544
Score: 0.941
Data Source: STRINGDB
LPCAT4
Tdark
Family: Enzyme
Novelty: 0.246654
Score: 0.925
Data Source: STRINGDB
GDPD3
Tbio
Family: Enzyme
Novelty: 0.18121762
Score: 0.906
Data Source: STRINGDB
GDPD1
Tbio
Family: Enzyme
Novelty: 0.28722153
Score: 0.9
Data Source: STRINGDB
ENPP2
Tchem
Family: Enzyme
Novelty: 0.00196928
Score: 0.9
Data Source: STRINGDB
ATP10D
Tdark
Family: Transporter
Novelty: 0.21272192
Score: 0.793
Data Source: STRINGDB
SIRPB1
Tbio
Novelty: 0.09889723
Score: 0.777
Data Source: STRINGDB
SIRPB1
Tbio
Novelty: 0.09889723
Score: 0.777
Data Source: STRINGDB
PLA2G1B
Tchem
Family: Enzyme
Novelty: 0.00064842
Score: 0.738
Data Source: STRINGDB
AGMO
Tbio
Family: Enzyme
Novelty: 0.03595131
Score: 0.737
Data Source: STRINGDB
Publication Statistics
PubMed Score  5.23

PubMed score by year
PubTator Score  2.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer