Tbio DPP10 Inactive dipeptidyl peptidase 10

Protein Summary

Description

Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:15454437). Has no dipeptidyl aminopeptidase activity (PubMed:12662155). This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Mutations in this gene have been associated with asthma. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8N608
• A8K1Q2
• J3KPP2
• J3KQ46
• Q0GLB8
• Q53QT3
• Q53S86
• Q53SL8
• Q53SS4
• Q6TTV4
• Q86YR9
• Q9P236

Gene Name

• DPP10

Ensembl ID

• ENST00000310323
• ENSP00000309066
• ENSG00000175497
• ENST00000393147
• ENSP00000376855
• ENST00000409163
• ENSP00000387038
• ENST00000410059
• ENSP00000386565

Symbol

• DPRP3
• KIAA1492
• DPL2
• DPPY
• DPRP3
• DPRP-3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	1
microRNA	0.79
transcription factor	0.7
gene perturbation	0.65
phenotype	0.65

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Serine Protease / Inactive Dipeptidyl Peptidase 10

Protein / Enzyme Modulator / Inactive Dipeptidyl Peptidase 10

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Inactive Dipeptidyl Peptidase 10

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.41   (req: < 5)

Gene RIFs: 27   (req: <= 3)

Antibodies: 308   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.41   (req: >= 5)

Gene RIFs: 27   (req: > 3)

Antibodies: 308   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0