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Tchem
AADAT
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial

Protein Summary
Description
Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro). This gene encodes a protein that is highly similar to mouse and rat kynurenine aminotransferase II. The rat protein is a homodimer with two transaminase activities. One activity is the transamination of alpha-aminoadipic acid, a final step in the saccaropine pathway which is the major pathway for L-lysine catabolism. The other activity involves the transamination of kynurenine to produce kynurenine acid, the precursor of kynurenic acid which has neuroprotective properties. Several transcript variants encoding two different isoforms have been found for this ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337664
  • ENSP00000336808
  • ENSG00000109576
  • ENST00000353187
  • ENSP00000226840
  • ENST00000509167
  • ENSP00000423190
  • ENST00000515480
  • ENSP00000423341

Symbol
  • KAT2
  • KAT2
  • KATII
  • KYAT2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.93
cell type or tissue
0.74
histone modification site profile
0.7
molecular function
0.67
PubMedID
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 151.2   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 307   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 151.2   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 307   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 54
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
2
4
89.6
chronotype measurement
1
1
1
6.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
89.6
chronotype measurement
1
6.7
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aminoadipate aminotransferase
VGNC:10812
461601
Mouse
MGI:1345167
23923
Rat
RGD:2948
29416
Dog
aminoadipate aminotransferase
VGNC:37407
486059
Horse
aminoadipate aminotransferase
VGNC:14886
100067095
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aminoadipate aminotransferase
Mouse
Rat
Dog
aminoadipate aminotransferase
Horse
aminoadipate aminotransferase
Protein Structure (15 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8N5Z0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 15
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (13)
Lysine catabolism (R-HSA-71064)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Lysine catabolism
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Tryptophan catabolism
Name
Explore in Pharos
Explore in Source
Lysine catabolism
Metabolism
Metabolism of amino acids and derivatives
Tryptophan catabolism
Protein-Protein Interactions (65)
1 – 10 of 65
SPACA3
Tbio
Family: Enzyme
Novelty: 0.04713334
p_int: 0.936986471
p_ni: 9e-9
p_wrong: 0.063013521
Score: 0.689
Data Source: BioPlex,STRINGDB
KYAT1
Tbio
Family: Enzyme
Novelty: 0.01232903
Score: 0.99
Data Source: STRINGDB
KMO
Tchem
Family: Enzyme
Novelty: 0.01469543
Score: 0.987
Data Source: STRINGDB
KYNU
Tchem
Family: Enzyme
Novelty: 0.01372383
Score: 0.982
Data Source: STRINGDB
AFMID
Tbio
Family: Enzyme
Novelty: 0.02027656
Score: 0.955
Data Source: STRINGDB
OGDH
Tbio
Family: Enzyme
Novelty: 0.00674601
Score: 0.95
Data Source: STRINGDB
DHTKD1
Tbio
Family: Enzyme
Novelty: 0.0381406
Score: 0.937
Data Source: STRINGDB
ALDH7A1
Tbio
Family: Enzyme
Novelty: 0.00069494
Score: 0.919
Data Source: STRINGDB
OGDHL
Tbio
Family: Enzyme
Novelty: 0.05079572
Score: 0.903
Data Source: STRINGDB
KYAT3
Tbio
Family: Enzyme
Novelty: 0.05845124
Score: 0.889
Data Source: STRINGDB
Publication Statistics
PubMed Score  151.20

PubMed score by year
PubTator Score  57.15

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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