Tchem AADAT Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial

Protein Summary

Description

Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro). This gene encodes a protein that is highly similar to mouse and rat kynurenine aminotransferase II. The rat protein is a homodimer with two transaminase activities. One activity is the transamination of alpha-aminoadipic acid, a final step in the saccaropine pathway which is the major pathway for L-lysine catabolism. The other activity involves the transamination of kynurenine to produce kynurenine acid, the precursor of kynurenic acid which has neuroprotective properties. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

Uniprot Accession IDs

• Q8N5Z0
• B3KP84
• Q9UL02
• KAT/AadAT

Gene Name

• AADAT

Ensembl ID

• ENST00000337664
• ENSP00000336808
• ENSG00000109576
• ENST00000353187
• ENSP00000226840
• ENST00000509167
• ENSP00000423190
• ENST00000515480
• ENSP00000423341

Symbol

• KAT2
• KAT2
• KATII
• KYAT2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.93
cell type or tissue	0.74
histone modification site profile	0.7
molecular function	0.67
PubMedID	0.59

Protein Classes

PANTHER Classes

Protein / Transferase / Transaminase / Kynurenine/alpha-aminoadipate Aminotransferase, Mitochondrial

DTO Classes

Protein / Enzyme / Transferase / Transaminase / Kynurenine/alpha-aminoadipate Aminotransferase, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 183.22   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 307   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 183.22   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 307   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 55

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0