You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
MSL3
Male-specific lethal 3 homolog

Protein Summary
Description
May be involved in chromatin remodeling and transcriptional regulation. May have a role in X inactivation. Component of the MSL complex which is responsible for the majority of histone H4 acetylation at 'Lys-16' which is implicated in the formation of higher-order chromatin structure. Specifically recognizes histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex. This gene encodes a nuclear protein that is similar to the product of the Drosophila male-specific lethal-3 gene. The Drosophila protein plays a critical role in a dosage-compensation pathway, which equalizes X-linked gene expression in males and females. Thus, the human protein is thought to play a similar function in chromatin remodeling and transcriptional regulation, and it has been found as part of a complex that is responsible for histone H4 lysine-16 acetylation. This gene can undergo X inactivation. Alternative splicing resul ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312196
  • ENSP00000312244
  • ENSG00000005302
  • ENST00000337339
  • ENSP00000338078
  • ENST00000361672
  • ENSP00000354562
  • ENST00000398527
  • ENSP00000381538
  • ENST00000482871
  • ENSP00000498064
  • ENST00000648013
  • ENSP00000497518
  • ENST00000649078
  • ENSP00000498017
  • ENST00000649271
  • ENSP00000496967
  • ENST00000649602
  • ENSP00000498168
  • ENST00000649649
  • ENSP00000497137
  • ENST00000649685
  • ENSP00000497496
  • ENST00000650215
  • ENSP00000496944
  • ENST00000650628
  • ENSP00000496838

Symbol
  • MSL3L1
  • MSL3L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
disease perturbation
0.98
transcription factor perturbation
0.94
microRNA
0.76
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.95   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 125   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.95   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (88)
FGFR1OP
Tbio
Novelty:  0.09922864
p_int:  0.999999937
p_ni:  6.2e-8
p_wrong:  1e-9
Score:  0.28
Data Source:  BioPlex,STRINGDB
MSL2
Tbio
Family:  Enzyme
Novelty:  0.01221658
p_int:  0.999999334
p_ni:  6.36e-7
p_wrong:  3e-8
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
BOD1
Tbio
Novelty:  0.06404805
p_int:  0.999998843
p_ni:  0.000001157
Score:  0.286
Data Source:  BioPlex,STRINGDB
MSL1
Tbio
Novelty:  3.71231442
p_int:  0.999922785
p_ni:  9e-8
p_wrong:  0.000077125
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
PLEKHA1
Tbio
Novelty:  0.03634462
p_int:  0.999887153
p_ni:  0.000112626
p_wrong:  2.22e-7
Score:  0.282
Data Source:  BioPlex,STRINGDB
KAT8
Tchem
Family:  Epigenetic
Novelty:  0.00861497
Score:  0.978
Data Source:  Reactome,STRINGDB
ING3
Tbio
Family:  Epigenetic
Novelty:  0.01696145
Score:  0.955
Data Source:  STRINGDB
DMAP1
Tbio
Family:  Enzyme
Novelty:  0.03152166
Score:  0.949
Data Source:  STRINGDB
KAT5
Tchem
Family:  Epigenetic
Novelty:  0.00368348
Score:  0.949
Data Source:  STRINGDB
EPC1
Tbio
Novelty:  0.03216371
Score:  0.939
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
HATs acetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
HATs acetylate histones
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
2
2
84.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
2
84.5
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MSL complex subunit 3
465491
Macaque
MSL complex subunit 3
720836
Mouse
MGI:1341851
17692
Rat
RGD:1549763
317464
Dog
MSL complex subunit 3
VGNC:54173
491742
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MSL complex subunit 3
Macaque
MSL complex subunit 3
Mouse
Rat
Dog
MSL complex subunit 3
Publication Statistics
PubMed Score 17.95
PubMed score by year
PubTator Score 6.23
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title