MSL3
Male-specific lethal 3 homolog
Protein Summary
May be involved in chromatin remodeling and transcriptional regulation. May have a role in X inactivation. Component of the MSL complex which is responsible for the majority of histone H4 acetylation at 'Lys-16' which is implicated in the formation of higher-order chromatin structure. Specifically recognizes histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex. This gene encodes a nuclear protein that is similar to the product of the Drosophila male-specific lethal-3 gene. The Drosophila protein plays a critical role in a dosage-compensation pathway, which equalizes X-linked gene expression in males and females. Thus, the human protein is thought to play a similar function in chromatin remodeling and transcriptional regulation, and it has been found as part of a complex that is responsible for histone H4 lysine-16 acetylation. This gene can undergo X inactivation. Alternative splicing resul ...more
- ENST00000312196
- ENSP00000312244
- ENSG00000005302
- ENST00000337339
- ENSP00000338078
- ENST00000361672
- ENSP00000354562
- ENST00000398527
- ENSP00000381538
- ENST00000482871
- ENSP00000498064
- ENST00000648013
- ENSP00000497518
- ENST00000649078
- ENSP00000498017
- ENST00000649271
- ENSP00000496967
- ENST00000649602
- ENSP00000498168
- ENST00000649649
- ENSP00000497137
- ENST00000649685
- ENSP00000497496
- ENST00000650215
- ENSP00000496944
- ENST00000650628
- ENSP00000496838
- MSL3L1
- MSL3L1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
co-expressed gene | 1 | ||
disease perturbation | 0.98 | ||
transcription factor perturbation | 0.94 | ||
microRNA | 0.76 | ||
protein domain | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 17.95 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 125 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 17.95 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 125 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0