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Tbio
EIF4E3
Eukaryotic translation initiation factor 4E type 3

Protein Summary
Description
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis. May act as an inhibitor of EIF4E1 activity (By similarity). EIF4E3 belongs to the EIF4E family of translational initiation factors that interact with the 5-prime cap structure of mRNA and recruit mRNA to the ribosome (Joshi et al., 2004 [PubMed 15153109]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295612
  • ENSP00000295612
  • ENSG00000163412
  • ENST00000389826
  • ENSP00000374476
  • ENST00000421769
  • ENSP00000411762
  • ENST00000425534
  • ENSP00000393324
  • ENST00000448225
  • ENSP00000410350

Symbol
  • eIF-4E3
  • eIF4E-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
virus perturbation
0.94
microRNA
0.72
tissue sample
0.71
PubMedID
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.61   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 87   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.61   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0