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Tbio
NGEF
Ephexin-1

Protein Summary
Description
Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264051
  • ENSP00000264051
  • ENSG00000066248
  • ENST00000373552
  • ENSP00000362653
  • ENST00000409079
  • ENSP00000387033

Symbol
  • EPHEXIN
  • ARHGEF27
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
transcription factor
0.62
biological process
0.6
PubMedID
0.6
gene perturbation
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.04   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 109   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.04   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (109)
PRKCD
Tclin
Family:  Kinase
Novelty:  0.0009758
p_int:  1
Score:  0.555
Data Source:  BioPlex,STRINGDB
SLC12A8
Tbio
Family:  Transporter
Novelty:  0.06012072
p_int:  0.999982989
p_ni:  0.00001701
p_wrong:  1e-9
Score:  0.485
Data Source:  BioPlex,STRINGDB
PRKCI
Tchem
Family:  Kinase
Novelty:  0.0076377
p_int:  0.991970848
p_ni:  0.008028852
p_wrong:  3e-7
Score:  0.244
Data Source:  BioPlex,STRINGDB
MRS2
Tbio
Novelty:  0.00264753
p_int:  0.925863125
p_ni:  0.07413687
p_wrong:  5e-9
Score:  0.185
Data Source:  BioPlex,STRINGDB
ACTR1B
Tbio
Novelty:  0.10014723
p_int:  0.898463278
p_ni:  0.101536722
Score:  0.363
Data Source:  BioPlex,STRINGDB
ACTR10
Tbio
Novelty:  0.11388846
p_int:  0.882231017
p_ni:  0.117768976
p_wrong:  7e-9
Score:  0.674
Data Source:  BioPlex,STRINGDB
EPHA4
Tchem
Family:  Kinase
Novelty:  0.00321698
Score:  0.989
Data Source:  STRINGDB
RHOB
Tbio
Family:  Enzyme
Novelty:  0.0019205
Score:  0.976
Data Source:  STRINGDB
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.972
Data Source:  STRINGDB
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
Score:  0.972
Data Source:  Reactome,STRINGDB
Pathways (68)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cell death signalling via NRAGE, NRIF and NADE
Reactome
Death Receptor Signalling
Reactome
Developmental Biology
Reactome
EPH-Ephrin signaling
Name
Explore in Pharos
Explore in Source
Axon guidance
Cell death signalling via NRAGE, NRIF and NADE
Death Receptor Signalling
Developmental Biology
EPH-Ephrin signaling
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bilirubin measurement
2
7
12
93.3
heel bone mineral density
3
2
3
93
mathematical ability
4
4
7
92.2
schizophrenia
6
2
1
1.1
91.4
educational attainment
1
4
4
79.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bilirubin measurement
12
93.3
heel bone mineral density
3
93
mathematical ability
7
92.2
schizophrenia
1
1.1
91.4
educational attainment
4
79.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neuronal guanine nucleotide exchange factor
VGNC:2709
460020
Macaque
neuronal guanine nucleotide exchange factor
713917
Mouse
MGI:1858414
53972
Rat
RGD:1309055
246217
Dog
neuronal guanine nucleotide exchange factor
VGNC:43795
486165
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neuronal guanine nucleotide exchange factor
Macaque
neuronal guanine nucleotide exchange factor
Mouse
Rat
Dog
neuronal guanine nucleotide exchange factor
Publication Statistics
PubMed Score 22.04
PubMed score by year
PubTator Score 8.37
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title