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Tdark
TBC1D19
TBC1 domain family member 19

Protein Summary
Description
May act as a GTPase-activating protein for Rab family protein(s).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264866
  • ENSP00000264866
  • ENSG00000109680
  • ENST00000511789
  • ENSP00000425569
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
cellular component
0.8
kinase perturbation
0.76
transcription factor binding site profile
0.68
virus perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.5   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 53   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.5   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 53   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Varicose veins
1
1
1
24.3
diastolic blood pressure
1
1
1
21.3
Agents acting on the renin-angiotensin system use measurement
1
1
1
6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Varicose veins
1
24.3
diastolic blood pressure
1
21.3
Agents acting on the renin-angiotensin system use measurement
1
6
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TBC1 domain family member 19
VGNC:2961
746753
Macaque
TBC1 domain family member 19
694865
Mouse
MGI:1914499
67249
Rat
RGD:1304958
289657
Dog
TBC1 domain family member 19
VGNC:47137
479121
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TBC1 domain family member 19
Macaque
TBC1 domain family member 19
Mouse
Rat
Dog
TBC1 domain family member 19
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8N5T2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (1)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (57)
1 – 10 of 57
TTLL1
Tdark
Family:  Enzyme
Novelty:  0.09244899
p_int:  0.999999025
p_ni:  9.69e-7
p_wrong:  6e-9
Score:  0.877
Data Source:  BioPlex,STRINGDB
LRRC49
Tdark
Novelty:  0.19477281
p_int:  0.99999377
p_ni:  4.5e-8
p_wrong:  0.000006185
Score:  0.843
Data Source:  BioPlex,STRINGDB
NICN1
Tdark
Novelty:  0.32909597
p_int:  0.999993029
p_ni:  7.6e-8
p_wrong:  0.000006894
Score:  0.829
Data Source:  BioPlex,STRINGDB
CCKAR
Tclin
Family:  GPCR
Novelty:  0.00152339
Score:  0.725
Data Source:  STRINGDB
ABCA13
Tbio
Family:  Transporter
Novelty:  0.03723754
Score:  0.72
Data Source:  STRINGDB
RILPL1
Tbio
Novelty:  0.04302386
Score:  0.72
Data Source:  STRINGDB
STIM2
Tbio
Novelty:  0.00446493
Score:  0.713
Data Source:  STRINGDB
TBC1D13
Tdark
Novelty:  0.60353273
Score:  0.653
Data Source:  STRINGDB
TBC1D30
Tbio
Novelty:  0.97335151
Score:  0.584
Data Source:  STRINGDB
TBC1D22B
Tbio
Novelty:  0.49852962
Score:  0.577
Data Source:  STRINGDB
Publication Statistics
PubMed Score  0.50

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer