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Tchem
CAMKK1
Calcium/calmodulin-dependent protein kinase kinase 1

Protein Summary
Description
Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000158166
  • ENSP00000158166
  • ENSG00000004660
  • ENST00000348335
  • ENSP00000323118

Symbol
  • CAMKKA
  • CAMKKA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
protein domain
0.85
transcription factor
0.75
microRNA
0.7
histone modification site profile
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.86   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 190   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.86   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 190   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (6)
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (50)
KIAA0355
Tdark
Novelty:  0.97113831
p_int:  0.999999656
p_ni:  3.44e-7
Score:  0.345
Data Source:  BioPlex,STRINGDB
TRIM11
Tbio
Family:  Enzyme
Novelty:  0.02243955
p_int:  0.999999473
p_ni:  5.27e-7
Data Source:  BioPlex
LPIN3
Tbio
Family:  Enzyme
Novelty:  0.01641336
p_int:  0.999960543
p_ni:  0.000039324
p_wrong:  1.33e-7
Score:  0.227
Data Source:  BioPlex,STRINGDB
IRGM
Tbio
Family:  Enzyme
Novelty:  0.0065731
p_int:  0.99994827
p_ni:  0.000050514
p_wrong:  0.000001217
Data Source:  BioPlex
RUVBL2
Tbio
Novelty:  0.01129017
p_int:  0.955870798
p_ni:  0.044129202
Score:  0.313
Data Source:  BioPlex,STRINGDB
RUVBL1
Tbio
Novelty:  0.0089115
p_int:  0.894584328
p_ni:  0.105415672
Score:  0.222
Data Source:  BioPlex,STRINGDB
CALM1
Tclin
Novelty:  0.00308267
Score:  0.976
Data Source:  Reactome,STRINGDB
CAMK4
Tbio
Family:  Kinase
Novelty:  0.00412444
Score:  0.962
Data Source:  Reactome,STRINGDB
CAMK2B
Tchem
Family:  Kinase
Novelty:  0.00793595
Score:  0.914
Data Source:  STRINGDB
CALM3
Tclin
Novelty:  0.00461552
Score:  0.911
Data Source:  STRINGDB
Pathways (42)
Activation of NMDA receptors and postsynaptic events (R-HSA-442755)

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Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Activation of RAC1 downstream of NMDARs
Reactome
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
Reactome
Ca-dependent events
Reactome
CaM pathway
Name
Explore in Pharos
Explore in Source
Activation of NMDA receptors and postsynaptic events
Activation of RAC1 downstream of NMDARs
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
Ca-dependent events
CaM pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
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Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
1
1
78.8
mean platelet volume
2
2
2
64
platelet count
2
2
2
58.1
Agents acting on the renin-angiotensin system use measurement
1
1
1
35.6
peak expiratory flow
1
1
1
27.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
78.8
mean platelet volume
2
64
platelet count
2
58.1
Agents acting on the renin-angiotensin system use measurement
1
35.6
peak expiratory flow
1
27.9
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Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calcium/calmodulin dependent protein kinase kinase 1
VGNC:12035
454438
Macaque
calcium/calmodulin dependent protein kinase kinase 1
707562
Mouse
MGI:1891766
55984
Rat
RGD:62023
60341
Dog
calcium/calmodulin dependent protein kinase kinase 1
VGNC:38683
611124
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calcium/calmodulin dependent protein kinase kinase 1
Macaque
calcium/calmodulin dependent protein kinase kinase 1
Mouse
Rat
Dog
calcium/calmodulin dependent protein kinase kinase 1
Publication Statistics
PubMed Score 17.86
PubMed score by year
PubTator Score 22.83
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title