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Tchem
CAMKK1
Calcium/calmodulin-dependent protein kinase kinase 1

Protein Summary
Description
Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000158166
  • ENSP00000158166
  • ENSG00000004660
  • ENST00000348335
  • ENSP00000323118

Symbol
  • CAMKKA
  • CAMKKA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
protein domain
0.85
transcription factor
0.75
microRNA
0.7
histone modification site profile
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.12   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 190   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.12   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 190   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (42)
Activation of NMDA receptors and postsynaptic events (R-HSA-442755)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Activation of RAC1 downstream of NMDARs
Reactome
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
Reactome
Ca-dependent events
Reactome
CaM pathway
Name
Explore in Pharos
Explore in Source
Activation of NMDA receptors and postsynaptic events
Activation of RAC1 downstream of NMDARs
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
Ca-dependent events
CaM pathway
Gene Ontology Terms (9)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (50)
1 – 10 of 50
KIAA0355
Tdark
Novelty: 0.97113831
p_int: 0.999999656
p_ni: 3.44e-7
Score: 0.345
Data Source: BioPlex,STRINGDB
TRIM11
Tbio
Family: Enzyme
Novelty: 0.02243955
p_int: 0.999999473
p_ni: 5.27e-7
Data Source: BioPlex
LPIN3
Tbio
Family: Enzyme
Novelty: 0.01641336
p_int: 0.999960543
p_ni: 0.000039324
p_wrong: 1.33e-7
Score: 0.227
Data Source: BioPlex,STRINGDB
IRGM
Tbio
Family: Enzyme
Novelty: 0.0065731
p_int: 0.99994827
p_ni: 0.000050514
p_wrong: 0.000001217
Data Source: BioPlex
RUVBL2
Tbio
Novelty: 0.01129017
p_int: 0.955870798
p_ni: 0.044129202
Score: 0.313
Data Source: BioPlex,STRINGDB
RUVBL1
Tbio
Novelty: 0.0089115
p_int: 0.894584328
p_ni: 0.105415672
Score: 0.222
Data Source: BioPlex,STRINGDB
CALM1
Tclin
Novelty: 0.00308267
Score: 0.976
Data Source: Reactome,STRINGDB
CAMK4
Tbio
Family: Kinase
Novelty: 0.00412444
Score: 0.962
Data Source: Reactome,STRINGDB
CAMK2B
Tchem
Family: Kinase
Novelty: 0.00793595
Score: 0.914
Data Source: STRINGDB
CALM3
Tclin
Novelty: 0.00461552
Score: 0.911
Data Source: STRINGDB
Publication Statistics
PubMed Score  14.12

PubMed score by year
PubTator Score  22.83

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer