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Tdark
MRPL50
39S ribosomal protein L50, mitochondrial

Protein Summary
Description
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a putative 39S subunit protein and belongs to the L47P ribosomal protein family. Pseudogenes corresponding to this gene are found on chromosomes 2p, 2q, 5p, and 10q. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374865
  • ENSP00000363999
  • ENSG00000136897

Symbol
  • MRP-L50
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.84
disease perturbation
0.79
small molecule perturbation
0.71
transcription factor binding site profile
0.65
transcription factor perturbation
0.61


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.75   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 127   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.75   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:107329
28028
Rat
RGD:1308008
362517
Dog
mitochondrial ribosomal protein L50
VGNC:43403
474785
Horse
mitochondrial ribosomal protein L50
VGNC:20348
100629329
Cow
mitochondrial ribosomal protein L50
VGNC:31645
514753
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
mitochondrial ribosomal protein L50
Horse
mitochondrial ribosomal protein L50
Cow
mitochondrial ribosomal protein L50
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8N5N7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Protein-Protein Interactions (130)
1 – 10 of 130
MRPS30
Tbio
Novelty: 0.08115544
p_int: 0.999999977
p_ni: 2.3e-8
Score: 0.995
Data Source: BioPlex,STRINGDB
MRPL47
Tbio
Novelty: 0.05648009
p_int: 0.999997389
p_ni: 0.000002611
Score: 0.998
Data Source: BioPlex,STRINGDB
MRPL42
Tbio
Novelty: 0.48241447
p_int: 0.999992532
p_ni: 0.000007468
Score: 0.994
Data Source: BioPlex,STRINGDB
MRPL10
Tbio
Novelty: 0.27087019
p_int: 0.999946993
p_ni: 0.000053007
Score: 0.978
Data Source: BioPlex,STRINGDB
MRPL4
Tdark
Novelty: 0.27290276
p_int: 0.99990775
p_ni: 0.00009225
Score: 0.997
Data Source: BioPlex,STRINGDB
MRPL55
Tdark
Novelty: 0.55956177
p_int: 0.999854615
p_ni: 0.000145385
Score: 0.979
Data Source: BioPlex,STRINGDB
MRPL45
Tdark
Novelty: 0.42464896
p_int: 0.999844866
p_ni: 0.000155134
Score: 0.996
Data Source: BioPlex,STRINGDB
MRPS18A
Tdark
Novelty: 0.26321707
p_int: 0.999793803
p_ni: 0.000206197
Score: 0.997
Data Source: BioPlex,STRINGDB
MRPL51
Tdark
Novelty: 0.24304433
p_int: 0.999601464
p_ni: 0.000398536
p_wrong: 1e-9
Score: 0.995
Data Source: BioPlex,STRINGDB
GADD45GIP1
Tbio
Novelty: 0.03765684
p_int: 0.999412095
p_ni: 0.000587905
Score: 0.996
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  0.75

PubMed score by year
PubTator Score  0.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer