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Tbio
ATPAF2
ATP synthase mitochondrial F1 complex assembly factor 2

Protein Summary
Description
May play a role in the assembly of the F1 component of the mitochondrial ATP synthase (ATPase). This gene encodes an assembly factor for the F(1) component of the mitochondrial ATP synthase. This protein binds specifically to the F1 alpha subunit and is thought to prevent this subunit from forming nonproductive homooligomers during enzyme assembly. This gene is located within the Smith-Magenis syndrome region on chromosome 17. An alternatively spliced transcript variant has been described, but its biological validity has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000474627
  • ENSP00000417190
  • ENSG00000171953

Symbol
  • ATP12
  • ATP12
  • ATP12p
  • LP3663
  • MC5DN1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
histone modification site profile
0.82
transcription factor binding site profile
0.79
transcription factor
0.68
tissue
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.22   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 119   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.22   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (124)
SPG21
Tbio
Family:  Enzyme
Novelty:  0.07929043
p_int:  0.999999936
p_ni:  6.1e-8
p_wrong:  3e-9
Score:  0.319
Data Source:  BioPlex,STRINGDB
FMC1
Tbio
Novelty:  0.06702205
p_int:  0.999999801
p_ni:  1.99e-7
Score:  0.96
Data Source:  BioPlex,STRINGDB
FECH
Tchem
Family:  Enzyme
Novelty:  0.00282289
p_int:  0.999995567
p_ni:  0.000004433
Score:  0.203
Data Source:  BioPlex,STRINGDB
NDUFAB1
Tclin
Novelty:  0.00190242
p_int:  0.999975874
p_ni:  0.000024126
Score:  0.447
Data Source:  BioPlex,STRINGDB
OXLD1
Tdark
Family:  Enzyme
Novelty:  23
p_int:  0.999630229
p_ni:  0.000369769
p_wrong:  2e-9
Score:  0.228
Data Source:  BioPlex,STRINGDB
KLHL22
Tbio
Novelty:  0.24456252
p_int:  0.998138814
p_ni:  0.001861186
Data Source:  BioPlex
MRM1
Tbio
Family:  Enzyme
Novelty:  0.08762499
p_int:  0.997541541
p_ni:  0.001995765
p_wrong:  0.000462694
Score:  0.402
Data Source:  BioPlex,STRINGDB
HINT2
Tbio
Novelty:  0.09560851
p_int:  0.997325948
p_ni:  0.002230059
p_wrong:  0.000443993
Data Source:  BioPlex
FAM124A
Tdark
Novelty:  1.51577847
p_int:  0.997138663
p_ni:  0.002386277
p_wrong:  0.00047506
Data Source:  BioPlex
ECHS1
Tbio
Family:  Enzyme
Novelty:  0.01291476
p_int:  0.992336533
p_ni:  0.007448851
p_wrong:  0.000214616
Score:  0.478
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
LIFEdb
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
2
4
93.9
waist-hip ratio
2
5
5
84.1
BMI-adjusted waist-hip ratio
2
4
4
79.8
HbA1c measurement
1
1
1
68.8
bone density
1
4
4
68.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
93.9
waist-hip ratio
5
84.1
BMI-adjusted waist-hip ratio
4
79.8
HbA1c measurement
1
68.8
bone density
4
68.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATP synthase mitochondrial F1 complex assembly factor 2
VGNC:9142
454483
Macaque
ATP synthase mitochondrial F1 complex assembly factor 2
699709
Mouse
MGI:2180561
246782
Rat
RGD:1305161
303190
Dog
ATP synthase mitochondrial F1 complex assembly factor 2
VGNC:38291
489539
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATP synthase mitochondrial F1 complex assembly factor 2
Macaque
ATP synthase mitochondrial F1 complex assembly factor 2
Mouse
Rat
Dog
ATP synthase mitochondrial F1 complex assembly factor 2
Publication Statistics
PubMed Score 24.22
PubMed score by year
PubTator Score 6.26
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title