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Tbio
SH2D3C
SH2 domain-containing protein 3C

Protein Summary
Description
Eph receptor-binding protein which may be a positive regulator of TCR signaling. Binding to BCAR1 is required to induce membrane ruffling and promote EGF-dependent cell migration (By similarity). This gene encodes an adaptor protein and member of a cytoplasmic protein family involved in cell migration. The encoded protein contains a putative Src homology 2 (SH2) domain and guanine nucleotide exchange factor-like domain which allows this signaling protein to form a complex with scaffolding protein Crk-associated substrate. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314830
  • ENSP00000317817
  • ENSG00000095370
  • ENST00000373276
  • ENSP00000362373
  • ENST00000373277
  • ENSP00000362374
  • ENST00000420366
  • ENSP00000388536
  • ENST00000429553
  • ENSP00000394632
  • ENST00000629203
  • ENSP00000485866

Symbol
  • NSP3
  • CHAT
  • NSP3
  • SHEP1
  • PRO34088
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.81
tissue sample
0.73
transcription factor
0.69
PubMedID
0.63
cell line
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 449.74   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 257   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 449.74   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 257   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0