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Tbio
SH2D3C
SH2 domain-containing protein 3C

Protein Summary
Description
Eph receptor-binding protein which may be a positive regulator of TCR signaling. Binding to BCAR1 is required to induce membrane ruffling and promote EGF-dependent cell migration (By similarity). This gene encodes an adaptor protein and member of a cytoplasmic protein family involved in cell migration. The encoded protein contains a putative Src homology 2 (SH2) domain and guanine nucleotide exchange factor-like domain which allows this signaling protein to form a complex with scaffolding protein Crk-associated substrate. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314830
  • ENSP00000317817
  • ENSG00000095370
  • ENST00000373276
  • ENSP00000362373
  • ENST00000373277
  • ENSP00000362374
  • ENST00000420366
  • ENSP00000388536
  • ENST00000429553
  • ENSP00000394632
  • ENST00000629203
  • ENSP00000485866

Symbol
  • NSP3
  • CHAT
  • NSP3
  • SHEP1
  • PRO34088
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.81
tissue sample
0.73
transcription factor
0.69
PubMedID
0.63
cell line
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 312.62   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 257   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 312.62   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 257   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (57)
BCAR1
Tbio
Novelty:  0.00329214
Score:  0.977
Data Source:  STRINGDB
PRSS57
Tbio
Family:  Enzyme
Novelty:  0.00250647
Score:  0.954
Data Source:  STRINGDB
SPECC1
Tbio
Novelty:  0.00830299
Score:  0.921
Data Source:  STRINGDB
NEDD9
Tbio
Novelty:  0.00539079
Score:  0.888
Data Source:  STRINGDB
MRPL58
Tbio
Family:  Enzyme
Novelty:  0.00178011
Score:  0.797
Data Source:  STRINGDB
BAG6
Tbio
Novelty:  0.0035578
Score:  0.795
Data Source:  STRINGDB
G3BP1
Tbio
Family:  Enzyme
Novelty:  0.00589987
Score:  0.738
Data Source:  STRINGDB
EIF4G1
Tbio
Novelty:  0.00170995
Score:  0.73
Data Source:  STRINGDB
C6orf48
Tdark
Novelty:  0.00615017
Score:  0.709
Data Source:  STRINGDB
EML3
Tdark
Novelty:  0.26210133
Score:  0.688
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
3
3
3
93.9
hematocrit
3
2
3
86.8
monocyte percentage of leukocytes
2
2
2
72.8
comparative body size at age 10, self-reported
1
1
1
58.4
neutrophil percentage of leukocytes
1
1
1
54.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
3
93.9
hematocrit
3
86.8
monocyte percentage of leukocytes
2
72.8
comparative body size at age 10, self-reported
1
58.4
neutrophil percentage of leukocytes
1
54.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SH2 domain containing 3C
VGNC:4862
464753
Macaque
SH2 domain containing 3C
699706
Mouse
MGI:1351631
27387
Rat
RGD:1307287
362111
Dog
SH2 domain containing 3C
VGNC:46113
491326
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SH2 domain containing 3C
Macaque
SH2 domain containing 3C
Mouse
Rat
Dog
SH2 domain containing 3C
Publication Statistics
PubMed Score 312.62
PubMed score by year
PubTator Score 174.37
PubTator score by year
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Related Publications
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PMID
Year
Title