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Tbio
MACO1
Macoilin

Protein Summary
Description
Plays a role in the regulation of neuronal activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374343
  • ENSP00000363463
  • ENSG00000204178
  • ENST00000399766
  • ENSP00000382668

Symbol
  • TMEM57
  • TMEM57
  • MACOILIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.67   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 74   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.67   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 74   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
2
4
97.6
low density lipoprotein cholesterol measurement
6
5
7
95.7
total cholesterol measurement
5
3
8
88.4
blood sedimentation
1
1
1
73.9
apolipoprotein B measurement
1
1
1
66.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
97.6
low density lipoprotein cholesterol measurement
7
95.7
total cholesterol measurement
8
88.4
blood sedimentation
1
73.9
apolipoprotein B measurement
1
66.9
Gene Ontology Terms (9)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (45)
1 – 10 of 45
B4GAT1
Tbio
Family: Enzyme
Novelty: 0.14959923
p_int: 0.968583222
p_ni: 0.031416778
Data Source: BioPlex
PCDHAC2
Tdark
Novelty: 0.28397695
p_int: 0.93377072
p_ni: 0.06622928
Score: 0.181
Data Source: BioPlex,STRINGDB
CDH5
Tbio
Novelty: 0.00072649
p_int: 0.914957713
p_ni: 0.085042287
Data Source: BioPlex
PCDHB11
Tdark
Novelty: 0.80480462
p_int: 0.893641667
p_ni: 0.106358333
Data Source: BioPlex
PLAC9
Tdark
Novelty: 0.23764669
p_int: 0.85996847
p_ni: 0.140031526
p_wrong: 4e-9
Data Source: BioPlex
LRRC55
Tbio
Family: IC
Novelty: 0.25121277
p_int: 0.844284938
p_ni: 0.155715062
Data Source: BioPlex
NKAIN1
Tdark
Family: Enzyme
Novelty: 0.52190272
p_int: 0.830738567
p_ni: 0.169261433
Data Source: BioPlex
C3AR1
Tchem
Family: GPCR
Novelty: 0.00527301
p_int: 0.810699387
p_ni: 0.189300613
Data Source: BioPlex
ATG14
Tbio
Novelty: 0.00914791
p_int: 0.754233017
p_ni: 0.245766982
Data Source: BioPlex
TMEM50A
Tdark
Novelty: 0.41718286
Score: 0.793
Data Source: STRINGDB
Publication Statistics
PubMed Score  6.67

PubMed score by year
PubTator Score  2.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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