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Tbio
NKAP
NF-kappa-B-activating protein

Protein Summary
Description
Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development. Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter. This gene encodes a protein that is involved in the activation of the ubiquitous transcription factor NF-kappaB. This protein is associated with the the histone deacetylase HDAC3 and with the Notch corepressor complex, and it thereby acts as a transcriptional repressor of Notch target genes. It is also required for alphabeta T cell development. A related pseudogene has been identified on chromosome X, while a related and intronless retrocopy, which has an intact CDS and may be functional, is located on chromosome 6. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371410
  • ENSP00000360464
  • ENSG00000101882
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.89
drug perturbation
0.71
tissue sample
0.68
histone modification site profile
0.62
ligand (protein) perturbation
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.16   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 128   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.16   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (87)
CSNK2A2
Tchem
Family:  Kinase
Novelty:  0.00231447
p_int:  0.999999998
p_ni:  2e-9
Score:  0.664
Data Source:  BioPlex,STRINGDB
NKAPL
Tbio
Novelty:  0.24172313
p_int:  0.999999979
p_ni:  2e-8
Score:  0.218
Data Source:  BioPlex,STRINGDB
NOS1AP
Tbio
Family:  Enzyme
Novelty:  0.0076555
p_int:  0.99999136
p_ni:  0.00000864
Score:  0.711
Data Source:  BioPlex,STRINGDB
DDX41
Tbio
Family:  Enzyme
Novelty:  0.01658581
p_int:  0.99998384
p_ni:  0.00001616
Score:  0.726
Data Source:  BioPlex,STRINGDB
C1orf226
Tdark
Novelty:  3.45031712
p_int:  0.999976975
p_ni:  0.00000856
p_wrong:  0.000014465
Score:  0.19
Data Source:  BioPlex,STRINGDB
CSNK2A1
Tchem
Family:  Kinase
Novelty:  0.00187855
p_int:  0.999970625
p_ni:  0.000029375
Score:  0.444
Data Source:  BioPlex,STRINGDB
JMJD6
Tchem
Family:  Enzyme
Novelty:  0.00305479
p_int:  0.999759283
p_ni:  0.000240717
Data Source:  BioPlex
NINL
Tbio
Novelty:  0.00726815
p_int:  0.999694167
p_ni:  0.000295559
p_wrong:  0.000010274
Data Source:  BioPlex
PRPF40A
Tbio
Novelty:  0.00898047
p_int:  0.998362015
p_ni:  0.001637985
Score:  0.817
Data Source:  BioPlex,STRINGDB
CHCHD4
Tbio
Novelty:  0.01204944
p_int:  0.998360964
p_ni:  0.001639036
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NFKB activating protein
VGNC:1215
465829
Macaque
NFKB activating protein
694891
Mouse
MGI:1914300
67050
Rat
RGD:1565955
298342
Dog
NFKB activating protein
VGNC:43826
492098
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NFKB activating protein
Macaque
NFKB activating protein
Mouse
Rat
Dog
NFKB activating protein
Publication Statistics
PubMed Score 28.16
PubMed score by year
PubTator Score 4.62
PubTator score by year
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Related Publications
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PMID
Year
Title