Pharos : Target Details

Tbio

Protein Summary

Description

Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development. Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter. This gene encodes a protein that is involved in the activation of the ubiquitous transcription factor NF-kappaB. This protein is associated with the the histone deacetylase HDAC3 and with the Notch corepressor complex, and it thereby acts as a transcriptional repressor of Notch target genes. It is also required for alphabeta T cell development. A related pseudogene has been identified on chromosome X, while a related and intronless retrocopy, which has an intact CDS and may be functional, is located on chromosome 6. [provided by RefSeq, May 2010]

Uniprot Accession IDs

Gene Name

NKAP

Ensembl ID

ENST00000371410
ENSP00000360464
ENSG00000101882

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.89

drug perturbation	0.71

tissue sample	0.68

histone modification site profile	0.62

ligand (protein) perturbation	0.59

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.16 (req: < 5)

View Publications

Gene RIFs: 5 (req: <= 3)

View Gene RIFs

Antibodies: 128 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.16 (req: >= 5)

Gene RIFs: 5 (req: > 3)

Antibodies: 128 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

No expression data found

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (87)

Explore Interacting Targets

1 – 10 of 87

See Interactions on String-DB

CSNK2A2

Tchem

Family: Kinase

Novelty: 0.00231447

p_int: 0.999999998

p_ni: 2e-9

Score: 0.664

Data Source: BioPlex,STRINGDB

NKAPL

Tbio

Novelty: 0.24172313

p_int: 0.999999979

p_ni: 2e-8

Score: 0.218

Data Source: BioPlex,STRINGDB

NOS1AP

Tbio

Family: Enzyme

Novelty: 0.0076555

p_int: 0.99999136

p_ni: 0.00000864

Score: 0.711

Data Source: BioPlex,STRINGDB

DDX41

Tbio

Family: Enzyme

Novelty: 0.01658581

p_int: 0.99998384

p_ni: 0.00001616

Score: 0.726

Data Source: BioPlex,STRINGDB

C1orf226

Tdark

Novelty: 3.45031712

p_int: 0.999976975

p_ni: 0.00000856

p_wrong: 0.000014465

Score: 0.19

Data Source: BioPlex,STRINGDB

CSNK2A1

Tchem

Family: Kinase

Novelty: 0.00187855

p_int: 0.999970625

p_ni: 0.000029375

Score: 0.444

Data Source: BioPlex,STRINGDB

JMJD6

Tchem

Family: Enzyme

Novelty: 0.00305479

p_int: 0.999759283

p_ni: 0.000240717

Data Source: BioPlex

NINL

Tbio

Novelty: 0.00726815

p_int: 0.999694167

p_ni: 0.000295559

p_wrong: 0.000010274

Data Source: BioPlex

PRPF40A

Tbio

Novelty: 0.00898047

p_int: 0.998362015

p_ni: 0.001637985

Score: 0.817

Data Source: BioPlex,STRINGDB

CHCHD4

Tbio

Novelty: 0.01204944

p_int: 0.998360964

p_ni: 0.001639036

Data Source: BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (13)

Functions (3)

Components (2)

Processes (8)

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Items per page:

1 – 3 of 3

GO Term	Evidence	Assigned by
chromatin binding	Inferred from Direct Assay (IDA)	UniProtKB

RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB

chromatin DNA binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations ()

No disease associations found

GWAS Traits (0)

No GWAS traits found

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UniProt Keyword

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No Header	No Header
Acetylation

Complete proteome

Isopeptide bond

Notch signaling pathway

Nucleus

Phosphoprotein

Polymorphism

Reference proteome

Repressor

Transcription

MGI Phenotype

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IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID
Chimp	NFKB activating protein	VGNC:1215	465829

Macaque	NFKB activating protein		694891

Mouse	NFKB activating protein	MGI:1914300	67050

Rat	NFKB activating protein	RGD:1565955	298342

Dog	NFKB activating protein	VGNC:43826	492098

Species	Name	OMA	EggNOG	Inparanoid
Chimp	NFKB activating protein

Macaque	NFKB activating protein

Mouse	NFKB activating protein

Rat	NFKB activating protein

Dog	NFKB activating protein

Publication Statistics

PubMed Score 28.16

PubMed score by year

PubTator Score 4.62

PubTator score by year

Related Publications

Text Mined References (18)

GeneRif Annotations (5)

Items per page:

0 of 0

PMID	Year	Title

No Header	No Header
endocrine/exocrine gland phenotype

hematopoietic system phenotype

immune system phenotype