Tbio TAB3 TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

Protein Summary

Description

Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor. The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8N5C8
• A6NDD9
• Q6VQR0

Gene Name

• TAB3

Ensembl ID

• ENST00000378930
• ENSP00000368212
• ENSG00000157625
• ENST00000378932
• ENSP00000368214
• ENST00000378933
• ENSP00000368215

Symbol

• MAP3K7IP3
• NAP1
• MAP3K7IP3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.85
histone modification site profile	0.76
pathway	0.76
cellular component	0.63
tissue sample	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.88   (req: < 5)

Gene RIFs: 25   (req: <= 3)

Antibodies: 258   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.88   (req: >= 5)

Gene RIFs: 25   (req: > 3)

Antibodies: 258   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0