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Tbio
TAB3
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

Protein Summary
Description
Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor. The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378930
  • ENSP00000368212
  • ENSG00000157625
  • ENST00000378932
  • ENSP00000368214
  • ENST00000378933
  • ENSP00000368215

Symbol
  • MAP3K7IP3
  • NAP1
  • MAP3K7IP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.85
histone modification site profile
0.76
pathway
0.76
cellular component
0.63
tissue sample
0.61


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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.9   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 258   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.9   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 258   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TGF-beta activated kinase 1 (MAP3K7) binding protein 3
VGNC:14720
473550
Macaque
TGF-beta activated kinase 1 and MAP3K7 binding protein 3
707630
Mouse
MGI:1913974
66724
Rat
RGD:1594527
317546
Dog
TGF-beta activated kinase 1 (MAP3K7) binding protein 3
VGNC:47060
491807
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TGF-beta activated kinase 1 (MAP3K7) binding protein 3
Macaque
TGF-beta activated kinase 1 and MAP3K7 binding protein 3
Mouse
Rat
Dog
TGF-beta activated kinase 1 (MAP3K7) binding protein 3
Pathways (52)
C-type lectin receptors (CLRs) (R-HSA-5621481)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 41
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
C-type lectin receptors (CLRs)
Reactome
CLEC7A (Dectin-1) signaling
Reactome
Cytokine Signaling in Immune system
Reactome
Death Receptor Signalling
Reactome
FCERI mediated NF-kB activation
Name
Explore in Pharos
Explore in Source
C-type lectin receptors (CLRs)
CLEC7A (Dectin-1) signaling
Cytokine Signaling in Immune system
Death Receptor Signalling
FCERI mediated NF-kB activation
Gene Ontology Terms (15)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (109)
1 – 10 of 109
TAB1
Tchem
Family: Kinase
Novelty: 0.00721424
p_int: 0.999999997
p_ni: 3e-9
Score: 0.996
Data Source: BioPlex,Reactome,STRINGDB
EMILIN1
Tbio
Novelty: 0.02550566
p_int: 0.999999929
p_ni: 3.2e-8
p_wrong: 3.9e-8
Score: 0.197
Data Source: BioPlex,STRINGDB
UBC
Tbio
Novelty: 0.00204643
Score: 0.997
Data Source: STRINGDB
MAP3K7
Tchem
Family: Kinase
Novelty: 0.00540177
Score: 0.995
Data Source: Reactome,STRINGDB
UBB
Tbio
Novelty: 0.00661254
Score: 0.995
Data Source: STRINGDB
UBA52
Tbio
Novelty: 0.01637744
Score: 0.995
Data Source: STRINGDB
IKBKG
Tbio
Family: Kinase
Novelty: 0.0006149
Score: 0.991
Data Source: Reactome,STRINGDB
TAB2
Tbio
Family: Enzyme
Novelty: 0.00635786
Score: 0.988
Data Source: Reactome,STRINGDB
RPS27A
Tbio
Novelty: 0.00658124
Score: 0.984
Data Source: STRINGDB
TRAF6
Tbio
Novelty: 0.00109366
Score: 0.98
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  50.90

PubMed score by year
PubTator Score  14.56

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer