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Tbio
ZGPAT
Zinc finger CCCH-type with G patch domain-containing protein

Protein Summary
Description
Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis. Isoform 4: Antagonizes the transcription repression by isoform 1 by competing for the binding of the NuRD complex. Does not bind DNA.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328969
  • ENSP00000332013
  • ENSG00000197114
  • ENST00000355969
  • ENSP00000348242
  • ENST00000357119
  • ENSP00000349634
  • ENST00000369967
  • ENSP00000358984
  • ENST00000448100
  • ENSP00000391176

Symbol
  • GPATC6
  • GPATCH6
  • KIAA1847
  • ZC3H9
  • ZC3HDC9
  • ZIP
  • ZIP
  • ZC3H9
  • GPATC6
  • GPATCH6
  • ZC3HDC9
  • KIAA1847
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.86
biological process
0.79
transcription factor binding site profile
0.77
phenotype
0.74
tissue sample
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.74   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.74   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.2
94.4
sex hormone-binding globulin measurement
2
1
2
87.5
2
2
0
1.1
84.1
smoking cessation
1
1
1
81
neutrophil count
2
2
2
75.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
94.4
sex hormone-binding globulin measurement
2
87.5
0
1.1
84.1
smoking cessation
1
81
neutrophil count
2
75.4
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger CCCH-type and G-patch domain containing
VGNC:10068
470003
Macaque
zinc finger CCCH-type and G-patch domain containing
719499
Mouse
MGI:2449939
229007
Rat
RGD:1310801
296478
Dog
zinc finger CCCH-type and G-patch domain containing
VGNC:54747
100687731
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger CCCH-type and G-patch domain containing
Macaque
zinc finger CCCH-type and G-patch domain containing
Mouse
Rat
Dog
zinc finger CCCH-type and G-patch domain containing
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (11)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (55)
1 – 10 of 55
LSM5
Tbio
Novelty: 0.12669584
p_int: 0.999989773
p_ni: 0.000010227
Score: 0.541
Data Source: BioPlex,STRINGDB
PRPF3
Tbio
Novelty: 0.01600014
p_int: 0.999971949
p_ni: 0.000028051
Score: 0.855
Data Source: BioPlex,STRINGDB
SPIN1
Tbio
Novelty: 0.00889909
p_int: 0.999061123
p_ni: 0.000935412
p_wrong: 0.000003465
Score: 0.259
Data Source: BioPlex,STRINGDB
SNRPE
Tbio
Novelty: 0.02033423
p_int: 0.99595095
p_ni: 0.00404905
Score: 0.174
Data Source: BioPlex,STRINGDB
FADS3
Tbio
Family: Enzyme
Novelty: 0.02899077
p_int: 0.995675396
p_ni: 0.004324586
p_wrong: 1.8e-8
Score: 0.183
Data Source: BioPlex,STRINGDB
LSM3
Tbio
Novelty: 0.05044984
p_int: 0.995612417
p_ni: 0.004387575
p_wrong: 8e-9
Data Source: BioPlex
PRPF4
Tchem
Novelty: 0.08229072
p_int: 0.995604247
p_ni: 0.004393543
p_wrong: 0.000002211
Score: 0.687
Data Source: BioPlex,STRINGDB
PNLIP
Tclin
Family: Enzyme
Novelty: 0.00043254
p_int: 0.977580384
p_ni: 0.022414059
p_wrong: 0.000005557
Score: 0.188
Data Source: BioPlex,STRINGDB
FAM153B
Tdark
Novelty: 4.34922003
p_int: 0.959863848
p_ni: 0.040094734
p_wrong: 0.000041418
Score: 0.19
Data Source: BioPlex,STRINGDB
ID2
Tbio
Family: TF
Novelty: 0.00256364
p_int: 0.959393717
p_ni: 0.040311538
p_wrong: 0.000294744
Data Source: BioPlex
Publication Statistics
PubMed Score  5.74

PubMed score by year
PubTator Score  16

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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