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Tdark
TTC39C
Tetratricopeptide repeat protein 39C

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304621
  • ENSP00000306598
  • ENSG00000168234
  • ENST00000317571
  • ENSP00000323645
  • ENST00000584250
  • ENSP00000464344

Symbol
  • C18orf17
  • HsT2697
  • C18orf17
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
microRNA
0.78
kinase perturbation
0.76
virus perturbation
0.68
cell type or tissue
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.4   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 18   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.4   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 18   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
1
2
2
82
monocyte percentage of leukocytes
1
1
1
61
leukocyte count
1
1
1
46.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
82
monocyte percentage of leukocytes
1
61
leukocyte count
1
46.9
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
tetratricopeptide repeat domain 39C
701560
Mouse
MGI:1919997
72747
Rat
RGD:1585423
686179
Dog
tetratricopeptide repeat domain 39C
VGNC:47958
480172
Horse
tetratricopeptide repeat domain 39C
VGNC:24631
100063448
Species
Name
OMA
EggNOG
Inparanoid
Macaque
tetratricopeptide repeat domain 39C
Mouse
Rat
Dog
tetratricopeptide repeat domain 39C
Horse
tetratricopeptide repeat domain 39C
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8N584-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (30)
1 – 10 of 30
TMEM43
Tbio
Novelty:  0.03549545
p_int:  0.794778513
p_ni:  0.205221487
Data Source:  BioPlex
TTC36
Tdark
Novelty:  0.27779241
Score:  0.634
Data Source:  STRINGDB
TTC5
Tbio
Novelty:  0.12127698
Score:  0.626
Data Source:  STRINGDB
TTC4
Tbio
Novelty:  0.00808711
Score:  0.626
Data Source:  STRINGDB
TTC9C
Tdark
Novelty:  0.85949913
Score:  0.626
Data Source:  STRINGDB
C18orf21
Tdark
Novelty:  0.65363998
Score:  0.558
Data Source:  STRINGDB
TMEM19
Tdark
Novelty:  1.22010943
Score:  0.533
Data Source:  STRINGDB
RIN3
Tbio
Novelty:  0.07790793
Score:  0.513
Data Source:  STRINGDB
CRK
Tchem
Novelty:  0.00238512
Score:  0.513
Data Source:  STRINGDB
BACH2
Tbio
Family:  TF
Novelty:  0.00932069
Score:  0.493
Data Source:  STRINGDB
Publication Statistics
PubMed Score  2.40

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer