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Tchem
DCLK2
Serine/threonine-protein kinase DCLK2

Protein Summary
Description
Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity). This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another fa ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296550
  • ENSP00000296550
  • ENSG00000170390
  • ENST00000302176
  • ENSP00000303887
  • ENST00000506325
  • ENSP00000427235

Symbol
  • DCAMKL2
  • DCDC3B
  • DCK2
  • CL2
  • DCK2
  • CLIK2
  • DCDC3
  • CLICK2
  • DCDC3B
  • DCAMKL2
  • CLICK-II
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
molecular function
0.9
small molecule
0.8
tissue sample
0.71
transcription factor
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.8   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 167   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.8   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.4
44.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.4
44.9
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (21)
1 – 10 of 21
FBLIM1
Tbio
Novelty: 0.0332985
p_int: 0.999998522
p_ni: 1.6e-8
p_wrong: 0.000001461
Data Source: BioPlex
PPP1R9B
Tbio
Novelty: 0.00676121
Score: 0.604
Data Source: STRINGDB
SYN1
Tbio
Novelty: 0.00093242
Score: 0.503
Data Source: STRINGDB
TANC2
Tdark
Novelty: 0.08495328
Score: 0.502
Data Source: STRINGDB
TECR
Tbio
Family: Enzyme
Novelty: 0.00114749
Score: 0.499
Data Source: STRINGDB
CLDN23
Tbio
Novelty: 0.12349944
Score: 0.498
Data Source: STRINGDB
SYN2
Tbio
Novelty: 0.00574709
Score: 0.494
Data Source: STRINGDB
CRTC2
Tbio
Novelty: 0.01888215
Score: 0.468
Data Source: STRINGDB
ZBBX
Tdark
Novelty: 1.66474399
Score: 0.465
Data Source: STRINGDB
SYN3
Tbio
Novelty: 0.0065245
Score: 0.462
Data Source: STRINGDB
Publication Statistics
PubMed Score  12.80

PubMed score by year
PubTator Score  7.63

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer