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Tbio
MREG
Melanoregulin

Protein Summary
Description
Plays a role in the incorporation of pigments into hair. May function in membrane fusion and regulate the biogenesis of disk membranes of photoreceptor rod cells (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263268
  • ENSP00000263268
  • ENSG00000118242
  • ENST00000620139
  • ENSP00000484331

Symbol
  • DSU
  • DSU
  • WDT2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.86
transcription factor binding site profile
0.86
transcription factor perturbation
0.8
histone modification site profile
0.7
microRNA
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.86   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 162   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.86   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 162   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.4
49.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.4
49.4
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
melanoregulin
VGNC:2023
459928
Macaque
melanoregulin
695056
Mouse
MGI:2151839
381269
Rat
RGD:1562333
501162
Dog
melanoregulin
VGNC:43362
610230
Species
Name
OMA
EggNOG
Inparanoid
Chimp
melanoregulin
Macaque
melanoregulin
Mouse
Rat
Dog
melanoregulin
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8N565-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (5)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (38)
1 – 10 of 38
SPAG9
Tbio
Family: Enzyme
Novelty: 0.00527315
p_int: 0.9964243
p_ni: 0.0035757
Score: 0.538
Data Source: BioPlex,STRINGDB
UBA5
Tbio
Novelty: 0.05089296
p_int: 0.983849665
p_ni: 0.016150335
Score: 0.234
Data Source: BioPlex,STRINGDB
HSP90AB4P
Tdark
p_int: 0.89486081
p_ni: 0.10513919
Data Source: BioPlex
FGFR1
Tclin
Family: Kinase
Novelty: 0.00055714
p_int: 0.790139729
p_ni: 0.209832382
p_wrong: 0.000027889
Score: 0.193
Data Source: BioPlex,STRINGDB
MYO5A
Tbio
Novelty: 0.00373224
Score: 0.804
Data Source: STRINGDB
RAB27A
Tchem
Family: Enzyme
Novelty: 0.00369416
Score: 0.761
Data Source: STRINGDB
PRPH2
Tbio
Novelty: 0.003038
Score: 0.736
Data Source: STRINGDB
MLPH
Tbio
Novelty: 0.01810421
Score: 0.723
Data Source: STRINGDB
PHF5A
Tbio
Family: Epigenetic
Novelty: 0.02989472
Score: 0.677
Data Source: STRINGDB
KRT23
Tbio
Novelty: 0.0533649
Score: 0.649
Data Source: STRINGDB
Publication Statistics
PubMed Score  52.86

PubMed score by year
PubTator Score  10.48

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer