Tbio OGFOD1 Prolyl 3-hydroxylase OGFOD1

Protein Summary

Description

Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro-62' of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. Involved in stress granule formation.

Uniprot Accession IDs

• Q8N543
• H3BUQ2
• Q9H7U5
• Q9H9J9
• Q9HA87
• Q9HCG0
• Q9NVB6

Gene Name

• OGFOD1

Ensembl ID

• ENST00000566157
• ENSP00000457258
• ENSG00000087263

Symbol

• KIAA1612
• TPA1
• TPA1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.95
histone modification site profile	0.86
molecular function	0.76
tissue sample	0.67
transcription factor binding site profile	0.67

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.49   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 154   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.49   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 154   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0