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Tbio
FIBCD1
Fibrinogen C domain-containing protein 1

Protein Classes
Protein Summary
Description
Acetyl group-binding receptor which shows a high-affinity and calcium-dependent binding to acetylated structures such as chitin, some N-acetylated carbohydrates, and amino acids, but not to their non-acetylated counterparts. Can facilitate the endocytosis of acetylated components. FIBCD1 is a conserved type II transmembrane endocytic receptor that binds chitin and is located primarily in the intestinal brush border (Schlosser et al., 2009 [PubMed 19710473]).[supplied by OMIM, Apr 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372338
  • ENSP00000361413
  • ENSG00000130720
  • ENST00000448616
  • ENSP00000414501
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.6
protein domain
0.58
cell type or tissue
0.55
transcription factor binding site profile
0.55
histone modification site profile
0.53


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.63   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 74   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.63   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 74   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
68.1
1
1
1
52.3
insomnia measurement
1
1
0
1
38.2
body height
1
1
1
19.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
68.1
1
52.3
insomnia measurement
0
1
38.2
body height
1
19.7
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
fibrinogen C domain containing 1
722440
Mouse
MGI:2138953
98970
Rat
RGD:9301596
103690010
Dog
fibrinogen C domain containing 1
VGNC:40877
491291
Cow
fibrinogen C domain containing 1
VGNC:29005
531723
Species
Name
OMA
EggNOG
Inparanoid
Macaque
fibrinogen C domain containing 1
Mouse
Rat
Dog
fibrinogen C domain containing 1
Cow
fibrinogen C domain containing 1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8N539-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (4)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (31)
1 – 10 of 31
WFIKKN2
Tbio
Novelty: 0.15855407
Score: 0.722
Data Source: STRINGDB
SH2D3C
Tbio
Novelty: 0.00356605
Score: 0.685
Data Source: STRINGDB
QRFP
Tbio
Novelty: 0.02210773
Score: 0.606
Data Source: STRINGDB
PGP
Tbio
Family: Enzyme
Novelty: 0.0225528
Score: 0.603
Data Source: STRINGDB
GRIN2A
Tclin
Family: IC
Novelty: 0.00060035
Score: 0.562
Data Source: STRINGDB
LAMC3
Tbio
Novelty: 0.02221768
Score: 0.556
Data Source: STRINGDB
KCT2
Tdark
Novelty: 0.61670099
Score: 0.552
Data Source: STRINGDB
SKI
Tbio
Novelty: 0.02109924
Score: 0.533
Data Source: STRINGDB
TMTC4
Tdark
Novelty: 0.53734704
Score: 0.525
Data Source: STRINGDB
DRD4
Tchem
Family: GPCR
Novelty: 0.00099622
Score: 0.524
Data Source: STRINGDB
Publication Statistics
PubMed Score  10.63

PubMed score by year
PubTator Score  6.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer