Tbio FIBCD1 Fibrinogen C domain-containing protein 1

Protein Summary

Description

Acetyl group-binding receptor which shows a high-affinity and calcium-dependent binding to acetylated structures such as chitin, some N-acetylated carbohydrates, and amino acids, but not to their non-acetylated counterparts. Can facilitate the endocytosis of acetylated components. FIBCD1 is a conserved type II transmembrane endocytic receptor that binds chitin and is located primarily in the intestinal brush border (Schlosser et al., 2009 [PubMed 19710473]).[supplied by OMIM, Apr 2010]

Uniprot Accession IDs

• Q8N539
• A3KFK0
• Q6UXK6
• Q96SJ7

Gene Name

• FIBCD1

Ensembl ID

• ENST00000372338
• ENSP00000361413
• ENSG00000130720
• ENST00000448616
• ENSP00000414501

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor	0.6
protein domain	0.58
cell type or tissue	0.55
transcription factor binding site profile	0.55
histone modification site profile	0.53

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Fibrinogen C Domain-containing Protein 1

DTO Classes

Protein / Signaling / Fibrinogen C Domain-containing Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.28   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 74   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.28   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 74   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0