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Tbio
CBR4
Carbonyl reductase family member 4

Protein Summary
Description
The heterotetramer with HSD17B8 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis (PubMed:19571038, PubMed:25203508). Within the heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD (PubMed:25203508). The homotetramer has NADPH-dependent quinone reductase activity (PubMed:19000905). Both homotetramer and the heterotetramer have broad substrate specificity and can reduce 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro) (PubMed:19000905, PubMed:19571038, PubMed:25203508).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306193
  • ENSP00000303525
  • ENSG00000145439
  • ENST00000504480
  • ENSP00000427615

Symbol
  • SDR45C1
  • SDR45C1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.89
disease perturbation
0.83
molecular function
0.73
tissue sample
0.68
virus perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.84   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 162   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.84   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 162   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (47)
HSD17B8
Tbio
Family:  Enzyme
Novelty:  0.00915958
p_int:  0.999900067
p_ni:  0.000099933
p_wrong:  1e-9
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
SEPT3
Tbio
Novelty:  0.008513
p_int:  0.867568462
p_ni:  0.132431538
Score:  0.808
Data Source:  BioPlex,STRINGDB
MCAT
Tbio
Family:  Enzyme
Novelty:  0.00600508
Score:  0.862
Data Source:  STRINGDB
OXSM
Tbio
Family:  Enzyme
Novelty:  0.00615894
Score:  0.832
Data Source:  STRINGDB
MECR
Tbio
Family:  Enzyme
Novelty:  0.01395965
Score:  0.804
Data Source:  STRINGDB
PDCL2
Tbio
Novelty:  0.10154162
Score:  0.801
Data Source:  STRINGDB
CBR3
Tbio
Family:  Enzyme
Novelty:  0.01874422
Score:  0.793
Data Source:  STRINGDB
HTD2
Tdark
Family:  Enzyme
Novelty:  0.15897211
Score:  0.752
Data Source:  STRINGDB
PHC3
Tbio
Novelty:  0.00091911
Score:  0.67
Data Source:  STRINGDB
CBR1
Tchem
Family:  Enzyme
Novelty:  0.0062295
Score:  0.66
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Fatty acid metabolism (R-HSA-8978868)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fatty acid metabolism
Reactome
Fatty acyl-CoA biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Fatty acid metabolism
Fatty acyl-CoA biosynthesis
Metabolism
Metabolism of lipids
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
2
4
57.7
autosomal dominant compelling helio-ophthalmic outburst syndrome
1
1
0
1.1
21
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
57.7
autosomal dominant compelling helio-ophthalmic outburst syndrome
0
1.1
21
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
carbonyl reductase 4
VGNC:10834
471344
Macaque
carbonyl reductase 4
693949
Mouse
MGI:2384567
234309
Rat
RGD:727826
359725
Dog
carbonyl reductase 4
VGNC:38765
477352
Species
Name
OMA
EggNOG
Inparanoid
Chimp
carbonyl reductase 4
Macaque
carbonyl reductase 4
Mouse
Rat
Dog
carbonyl reductase 4
Publication Statistics
PubMed Score 9.84
PubMed score by year
PubTator Score 55.69
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title