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Tbio
MARVELD2
MARVEL domain-containing protein 2

Protein Summary
Description
Plays a role in the formation of tricellular tight junctions and of epithelial barriers (By similarity). Required for normal hearing via its role in the separation of the endolymphatic and perilymphatic spaces of the organ of Corti in the inner ear, and for normal survival of hair cells in the organ of Corti (PubMed:17186462). The protein encoded by this gene is a membrane protein found at the tight junctions between epithelial cells. The encoded protein helps establish epithelial barriers such as those in the organ of Corti, where these barriers are required for normal hearing. Defects in this gene are a cause of deafness autosomal recessive type 49 (DFNB49). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325631
  • ENSP00000323264
  • ENSG00000152939
  • ENST00000454295
  • ENSP00000396244
  • ENST00000614617
  • ENSP00000480044
  • ENSG00000274671
  • ENST00000622835
  • ENSP00000480068
  • ENST00000645446
  • ENSP00000494616
  • ENST00000646733
  • ENSP00000496750
  • ENST00000647531
  • ENSP00000493858

Symbol
  • TRIC
  • Tric
  • DFNB49
  • MARVD2
  • MRVLDC2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.91
virus perturbation
0.85
disease perturbation
0.79
cellular component
0.75
transcription factor perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.69   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 152   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.69   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (14)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (69)
1 – 10 of 69
STK38
Tbio
Family: Kinase
Novelty: 0.03242123
p_int: 0.999999467
p_ni: 5.25e-7
p_wrong: 8e-9
Score: 0.269
Data Source: BioPlex,STRINGDB
TTL
Tchem
Family: Enzyme
Novelty: 0.03494724
p_int: 0.999998646
p_ni: 7.01e-7
p_wrong: 6.54e-7
Score: 0.199
Data Source: BioPlex,STRINGDB
CTBS
Tbio
Family: Enzyme
Novelty: 0.00956005
p_int: 0.999997582
p_ni: 0.00000174
p_wrong: 6.79e-7
Score: 0.325
Data Source: BioPlex,STRINGDB
ACAD9
Tbio
Family: Enzyme
Novelty: 0.03238308
p_int: 0.972666022
p_ni: 0.027333978
Score: 0.514
Data Source: BioPlex,STRINGDB
BAIAP2L1
Tbio
Novelty: 0.06381886
p_int: 0.97129349
p_ni: 0.014796904
p_wrong: 0.013909606
Score: 0.25
Data Source: BioPlex,STRINGDB
NDUFAF1
Tclin
Novelty: 0.05630549
p_int: 0.96107895
p_ni: 0.03892105
Score: 0.552
Data Source: BioPlex,STRINGDB
RAP2A
Tbio
Family: Enzyme
Novelty: 0.00541101
p_int: 0.91484625
p_ni: 0.085153721
p_wrong: 2.8e-8
Score: 0.188
Data Source: BioPlex,STRINGDB
ECSIT
Tbio
Novelty: 0.04690184
p_int: 0.844868744
p_ni: 0.155131255
p_wrong: 1e-9
Score: 0.542
Data Source: BioPlex,STRINGDB
GAP43
Tbio
Novelty: 0.00091023
p_int: 0.829942659
p_ni: 0.170057326
p_wrong: 1.5e-8
Score: 0.169
Data Source: BioPlex,STRINGDB
MARVELD3
Tbio
Novelty: 0.10486289
Score: 0.92
Data Source: STRINGDB
Publication Statistics
PubMed Score  82.69

PubMed score by year
PubTator Score  188.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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