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Tbio
ZADH2
Prostaglandin reductase 3

Protein Summary
Description
Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest efficienty towards 15-keto-PGE2-alpha. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322342
  • ENSP00000323678
  • ENSG00000180011
  • ENST00000537114
  • ENSP00000440111

Symbol
  • PTGR3
  • PRG-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.92
transcription factor binding site profile
0.86
protein domain
0.85
kinase perturbation
0.84
disease perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.64   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 133   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.64   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
SLC9A3R2
Tchem
Family:  Transporter
Novelty:  0.01401705
p_int:  0.999926962
p_ni:  0.000073038
Data Source:  BioPlex
MAD1L1
Tbio
Novelty:  0.03550138
p_int:  0.999920552
p_ni:  0.000079445
p_wrong:  3e-9
Score:  0.191
Data Source:  BioPlex,STRINGDB
CCNB1
Tchem
Novelty:  0.0005503
p_int:  0.984226495
p_ni:  0.015773447
p_wrong:  5.7e-8
Score:  0.618
Data Source:  BioPlex,STRINGDB
FGL1
Tbio
Novelty:  0.02650803
p_int:  0.980269744
p_ni:  0.019730256
Data Source:  BioPlex
C7orf43
Tdark
Novelty:  1.11975505
p_int:  0.961449045
p_ni:  0.03855089
p_wrong:  6.5e-8
Score:  0.188
Data Source:  BioPlex,STRINGDB
DBT
Tbio
Family:  Enzyme
Novelty:  0.0070589
p_int:  0.944099912
p_ni:  0.055900086
p_wrong:  2e-9
Score:  0.177
Data Source:  BioPlex,STRINGDB
TRAPPC10
Tbio
Novelty:  0.03433058
p_int:  0.935138542
p_ni:  0.064861458
Score:  0.166
Data Source:  BioPlex,STRINGDB
CKS2
Tbio
Family:  Enzyme
Novelty:  0.02482411
p_int:  0.753623468
p_ni:  0.246151891
p_wrong:  0.000224641
Score:  0.667
Data Source:  BioPlex,STRINGDB
SMIM21
Tdark
Novelty:  1.27326849
Score:  0.669
Data Source:  STRINGDB
ZNF407
Tbio
Family:  TF
Novelty:  0.16936176
Score:  0.652
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
brain volume measurement
5
3
5
71.2
platelet count
2
2
2
64.5
vascular endothelial growth factor measurement
1
1
1
62.7
smoking status measurement
2
1
2
49.6
1
1
1
40.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
brain volume measurement
5
71.2
platelet count
2
64.5
vascular endothelial growth factor measurement
1
62.7
smoking status measurement
2
49.6
1
40.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
zinc binding alcohol dehydrogenase domain containing 2
701079
Mouse
MGI:2444835
225791
Rat
RGD:1309999
291403
Dog
zinc binding alcohol dehydrogenase domain containing 2
VGNC:48511
476162
Horse
zinc binding alcohol dehydrogenase domain containing 2
VGNC:25123
100061958
Species
Name
OMA
EggNOG
Inparanoid
Macaque
zinc binding alcohol dehydrogenase domain containing 2
Mouse
Rat
Dog
zinc binding alcohol dehydrogenase domain containing 2
Horse
zinc binding alcohol dehydrogenase domain containing 2
Publication Statistics
PubMed Score 8.64
PubMed score by year
PubTator Score 3.02
PubTator score by year
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Related Publications
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PMID
Year
Title