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Tbio
TTC30B
Tetratricopeptide repeat protein 30B

Protein Summary
Description
Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000408939
  • ENSP00000386181
  • ENSG00000196659

Symbol
  • IFT70
  • fleer
  • IFT70B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
gene perturbation
0.73
tissue sample
0.63
virus perturbation
0.59
protein domain
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.81   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.81   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (64)
IFT57
Tbio
Novelty:  0.03373199
p_int:  0.999999997
p_ni:  3e-9
Score:  0.995
Data Source:  BioPlex,STRINGDB
IFT52
Tbio
Novelty:  0.04183122
p_int:  0.999999812
p_ni:  1.88e-7
Score:  0.998
Data Source:  BioPlex,STRINGDB
CLUAP1
Tbio
Novelty:  0.08002286
p_int:  0.999999802
p_ni:  1.97e-7
Score:  0.992
Data Source:  BioPlex,STRINGDB
IFT46
Tdark
Novelty:  0.11310911
p_int:  0.999999733
p_ni:  2.65e-7
p_wrong:  2e-9
Score:  0.997
Data Source:  BioPlex,STRINGDB
IFT81
Tbio
Novelty:  0.01610195
p_int:  0.999999682
p_ni:  3.18e-7
Score:  0.993
Data Source:  BioPlex,STRINGDB
IFT88
Tbio
Novelty:  0.00727114
p_int:  0.99999939
p_ni:  7.5e-8
p_wrong:  5.35e-7
Score:  0.992
Data Source:  BioPlex,STRINGDB
IFT27
Tbio
Family:  Enzyme
Novelty:  0.05592902
p_int:  0.999999037
p_ni:  9.63e-7
Score:  0.981
Data Source:  BioPlex,STRINGDB
IFT80
Tbio
Novelty:  0.04862973
p_int:  0.999998391
p_ni:  6.6e-7
p_wrong:  9.49e-7
Score:  0.99
Data Source:  BioPlex,STRINGDB
IFT22
Tbio
Family:  Enzyme
Novelty:  0.18342877
p_int:  0.99999719
p_ni:  0.00000281
Score:  0.994
Data Source:  BioPlex,STRINGDB
IFT74
Tbio
Novelty:  0.07195266
p_int:  0.999996787
p_ni:  0.000003213
Score:  0.996
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Cilium Assembly (R-HSA-5617833)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cilium Assembly
Reactome
Intraflagellar transport
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
Cilium Assembly
Intraflagellar transport
Organelle biogenesis and maintenance
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
1
1
1
56.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
1
56.2
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1919671
72421
Rat
RGD:1590784
499814
Dog
tetratricopeptide repeat domain 30B
610209
Cow
tetratricopeptide repeat domain 30A
510160
Cow
tetratricopeptide repeat domain 30B
538713
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
tetratricopeptide repeat domain 30B
Cow
tetratricopeptide repeat domain 30A
Cow
tetratricopeptide repeat domain 30B
Publication Statistics
PubMed Score 10.81
PubMed score by year
PubTator Score 11.42
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title