Tbio TTC30B Tetratricopeptide repeat protein 30B

Protein Summary

Description

Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.

Uniprot Accession IDs

• Q8N4P2
• Q63HQ1
• Q96NE6
• TPR repeat protein 30B

Gene Name

• TTC30B

Ensembl ID

• ENST00000408939
• ENSP00000386181
• ENSG00000196659

Symbol

• IFT70
• fleer
• IFT70B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.89
gene perturbation	0.73
tissue sample	0.63
virus perturbation	0.59
protein domain	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.37   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 91   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.37   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0